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NIDA Notes Articles: Addiction Science

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Dr. Evan D. Kharasch Joins the Institute of Medicine

December 2013

Dr. Kharasch is a NIDA-funded researcher known for a broad range of research into how drugs are metabolized in the body.

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Prefrontal Cortex Stimulation Stops Compulsive Drug Seeking in Rats

January 2014

Researchers have shut down laboratory rats’ compulsive cocaine seeking by stimulating an area of the animals’ prefrontal cortex. The finding raises the possibility that stimulating neurons in this brain area may weaken or break cocaine’s grip on the behavior of people who are addicted to the drug.

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Stress-Induced Enzyme Compounds Methamphetamine Neurotoxicity

January 2014

Ketoprofen, an anti-inflammatory agent commonly prescribed to treat arthritis, reduces neuronal damage in rats that have been exposed to chronic stress and methamphetamine. If this finding of a recent NIDA-supported study extrapolates to humans, anti-inflammatory medications may gain a place in the treatment of methamphetamine addiction.

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Methamphetamine Alters Brain Structures, Impairs Mental Flexibility

March 2014

Methamphetamine alters brain structures involved in decision-making and impairs the ability to suppress habitual behaviors that have become useless or counterproductive. The two effects were correlated, indicating that the structural change underlies the decline in mental flexibility.

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