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NIDA Notes Articles: Basic Science

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Chromosome 17 Harbors Opioid Dependence Genes

March 2008

Describes the work of researchers who have found a statistical link between one region on chromosome 17 and an increased risk of opioid dependence.

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Brain Proteins Differ in Cocaine-Overdose Victims

December 2008

Describes research findings showing differences in protein concentrations in the brain pleasure centers of people who died from cocaine overdose as compared with those who did not abuse the drug.

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Brain Opioid Receptor Levels Predict Time to Cocaine Relapse

October 2010
Describes study findings revealing that cocaine abusers who maintain high levels of a certain receptor in their brain during early abstinence relapse sooner than abusers whose levels drop.

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Brain Adaptation May Dampen Effects of Cocaine

October 2010
Reports evidence that a cocaine-induced change in the structure of brain cells represents an adaptive response that may limit the drug’s impact.

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Animal Studies Elaborate Toluene's Effects

June 2008

Reports on evidence that toluene abuse can harm the nervous system and body, although scientists know relatively little about its specific actions.

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Adolescent Rats Self-Administer More Nicotine Than Adults

April 2009

Highlights an animal study involving the self-administration of nicotine among adolescent and adult rats to gain understanding of their potential vulnerability to the substance.

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