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NIDA

NIDA Notes Articles: Basic Science

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Dr. Antonello Bonci Q & A: Lighting Up the Brain To Shut Down Cocaine Seeking

July 2014

The Scientific Director of NIDA’s Intramural Research Program talks about switching off animals’ compulsive cocaine seeking by optogenetically activating the prefrontal cortex, and the implications of this work for people. In an accompanying podcast, Dr. Bonci walks viewers through experiments that showed that prefrontal cortex activity levels may constitute a simple switch controlling whether or not animals compulsively seek cocaine.

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A Genetic Nexus of Obesity and Smoking

October 2014

Research shows that some gene variants that influence body mass index also shape smoking behaviors.

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Animation: The Rise and Fall of the Cocaine High

November 2014

This animation shows the rapid passage of cocaine through the brain. It demonstrates that the intensity of the cocaine “high” parallels the trajectory of cocaine levels in the brain.

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Study Assesses Functional Deficits Due to HIV and Methamphetamine Use

November 2014

Methamphetamine use and HIV infection raise the risk for functional dependence, or the need for assistance with everyday tasks. People who use methamphetamine and are HIV positive showed the highest levels of functional dependence in most domains of daily life.

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