En español
NIDA

NIDA Notes Articles: Basic Science

NIDA Notes Category Graphic

Gene Variants Reduce Opioid Risks

June 2014

Two recent studies suggest that genotyping may enable clinicians to base therapies on individual patients’ potential responsiveness to opioid drugs’ therapeutic effects and vulnerability to their harmful effects.

NIDA Notes Category Graphic

Dr. Antonello Bonci Q & A: Lighting Up the Brain To Shut Down Cocaine Seeking

July 2014

The Scientific Director of NIDA’s Intramural Research Program talks about switching off animals’ compulsive cocaine seeking by optogenetically activating the prefrontal cortex, and the implications of this work for people. In an accompanying podcast, Dr. Bonci walks viewers through experiments that showed that prefrontal cortex activity levels may constitute a simple switch controlling whether or not animals compulsively seek cocaine.

NIDA Notes Category Graphic

A Genetic Nexus of Obesity and Smoking

October 2014

Research shows that some gene variants that influence body mass index also shape smoking behaviors.

NIDA Notes Category Graphic

Animation: The Rise and Fall of the Cocaine High

November 2014

This animation shows the rapid passage of cocaine through the brain. It demonstrates that the intensity of the cocaine “high” parallels the trajectory of cocaine levels in the brain.

NIDA Notes Category Graphic

Study Assesses Functional Deficits Due to HIV and Methamphetamine Use

November 2014

Methamphetamine use and HIV infection raise the risk for functional dependence, or the need for assistance with everyday tasks. People who use methamphetamine and are HIV positive showed the highest levels of functional dependence in most domains of daily life.

NIDA Notes Category Graphic

Animal Study Suggests Marijuana May Affect Future Offspring’s Susceptibility to Heroin

February 2015

Can marijuana use put offspring at heightened risk for opiate addiction, even if the use stops before the offspring are conceived? Results from a recent NIDA-funded study are consistent with other studies suggesting that a parent’s history of drug use, even preconception, may affect a child’s brain function and behavior.

NIDA Notes Category Graphic

Stress Hormone Sets the Stage for Relapse to Cocaine Use

June 2015

A stressed rat will seek a dose of cocaine that is too weak to motivate an unstressed rat. Researchers traced the physiological pathway that links stress and the stress hormone corticosterone to increased dopamine activity and heightened responsiveness to cocaine.

Pages

NIDA Notes

Tags

Drug Topics

Drugs of Abuse

Population Groups

Related Topics