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NIDA Notes Articles: Basic Science
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Stress Response May Underlie African- Americans' Reduced Pain Tolerance

October 2006

Summarizes research suggesting a physiological difference as the explanation for African-Americans' reported low tolerance for pain.
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Methamphetamine Restricts Fetal Growth, Increases Lethargy in Newborns

June 2008

Reports on research showing that newborns whose mothers abused methamphetamine during pregnancy showed lower rates of fetal growth as compared with unexposed newborns.
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Optical Technologies Expand Vistas Into the Brain

September 2008

Describes new tools under development, including one to visualize cells deep in the brain and another one that remotely activates brain cells.
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New Technique Links 89 Genes to Drug Dependence

September 2008

Presents research findings linking 89 genes to drug abuse and dependence, found using genome-wide association studies, a new technique for identifying genes.
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Immune System Plays Unexpected Role in Brain Development

September 2008

Describes research findings demonstrating that the immune system participates in the shaping of brain circuits during a child's development, a finding that may shed light on the origins of neurodegenerative diseases.
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Long-Term Cocaine Self-Administration Depresses Brain Activity

December 2008

Discusses research exploring how widespread the reduction of neural activity is in the brain with chronic exposure to cocaine.
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Brain Proteins Differ in Cocaine-Overdose Victims

December 2008

Describes research findings showing differences in protein concentrations in the brain pleasure centers of people who died from cocaine overdose as compared with those who did not abuse the drug.
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Imaging Studies Elucidate Neurobiology of Cigarette Craving

December 2008

Reports on three separate imaging studies illuminating the neurobiology of cigarette craving.
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Prenatal Nicotine Exposure May Damage Receptors That Influence Auditory Processing

April 2009

Reports on a series of animal experiments indicating that nicotine exposure during prenatal fetal development damages a set of receptors in the brain's auditory processing center.
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Damage to Brain Area May Immediately Halt Cigarette Addiction

April 2009

Describes a study among people who had sustained brain injuries to investigate whether certain damaged areas of the brain are associated with the ability to quit smoking.

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