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NIDA Notes Articles: Treatment

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Buprenorphine During Pregnancy Reduces Neonate Distress

July 2012

Sublingual buprenorphine is a safe and effective alternative to methadone for treating opioid dependence during pregnancy, finds the Maternal Opioid Treatment: Human Experimental Research (MOTHER) study, a NIDA-supported clinical trial. Women who received either medication had similar pregnancy and birth outcomes, but infants born to women who received buprenorphine had milder symptoms of neonatal opioid withdrawal.

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Brief Intervention Helps Adolescents Curb Substance Use

January 2013

NIDA-funded researchers have gathered evidence that brief interventions can help adolescents move away from drug use. In a clinical trial, middle and high school students markedly reduced their substance use following two 60-minute sessions that combined motivational interviewing and cognitive behavioral therapy.

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Brain Responds to Marijuana Cues in Familiar Manner

March 2011
Researchers found that the brain activity that takes place when cues trigger marijuana cravings is similar to the activity that accompanies cravings for other drugs.

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Basic Science Discoveries Yield Novel Approaches to Analgesia

September 2008

Describes research to develop new compounds that match or exceed the pain relief provided by opioids while avoiding their shortcomings.

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Attention to Bipolar Disorder Strengthens Substance Abuse Treatment

April 2010

Describes a study of participants who had both substance abuse and bipolar disorder to investigate the potential benefits of integrated group therapy for this population.

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Aripiprazole Prevents Rats From Resuming Cocaine Seeking

December 2008

Reports on study results indicating a medication prescribed for schizophrenia and manic phases of bipolar disorder shows promise as a cocaine addiction treatment.

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Antiretroviral Treatment Reduces Spread of HIV Among Injection Drug Users

April 2012

Expanded use of antiretroviral therapy in British Columbia reduced the spread of HIV among injection drug users and others in the province.

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Anticipation of Methadone Enhances Brain Reactivity to Heroin Cues

December 2009

Describes findings of a study revealing that images of heroin preparation and injection can incite craving and excite brain areas associated with reward-seeking even in methadone-maintained patients.

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Antibody Fragment Removes Methamphetamine From the Brain

November 2009

Reports animal study findings on development of an antibody fragment that rapidly removes methamphetamine from the brain and discusses implications for treatment of overdose.

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Animation: Building an Anti-Drug Vaccine

December 2012

The immune system has an extraordinary ability to recognize compounds foreign to the body and eliminate them. NIDA-sponsored scientists are working to harness this ability to create vaccines that will protect individuals against the psychogenic and addictive effects of abused drugs. This animation shows one of the most promising strategies, which has already yielded partial success in producing effective vaccines against nicotine, cocaine, and other drugs.

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