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NIDA Notes Articles: Treatment

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Medications That Normalize Brain Glutamate Reduce Drug-Seeking in Rats

October 2010
Reports on two studies that demonstrate the promise of treating addiction with medications that alleviate drug-induced alterations in signaling by the neurotransmitter glutamate.

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Medication Reduces Rats' Return to Methamphetamine Seeking

July 2011

Reports on a new medication strategy under investigated in animal studies that shows promise for preventing relapse to drug abuse.

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Lofexidine May Enhance Naltrexone Efficacy

December 2008

Highlights results from a pilot study suggesting that lofexidine, an anti-hypertensive medication, can enhance success rates among patients taking maintenance naltrexone to avoid opioid relapse.

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Legal Pressure Increases Treatment Retention

April 2009

Presents data on the length of stay in substance abuse treatment among people who were in treatment as a result of legal pressure as compared with those in treatment voluntarily.

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Intervention Improves Employment Outlook For Methadone Patients

June 2008

Describes a study of unemployed methadone patients and the use of assertive outreach and motivational techniques to improve the patients’ employment outlook.

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Intervention Improves Abstinence, Employment Among Welfare Recipients

December 2010
Reports research to study the effectiveness of an intensive case management program to aid female substance abusers who receive welfare in staying off drugs and finding employment.

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Intervention Boosts Treatment Participation, Abstinence Among Depressed Women

July 2012
Intensive case management was more effective in increasing treatment engagement and reducing alcohol consumption among depressed participants than among those who were not depressed, according to a followup analysis of a substance abuse treatment study involving women on welfare.

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HIV Treatment Interruption Is Pervasive After Release From Texas Prisons

March 2011

Describes a study revealing that HIV-infected prisoners in Texas often experience an interruption in treatment following their release and that assistance in filling out paperwork can reduce these interruptions.

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HIV Infection Accelerates Hepatitis C–Related Liver Fibrosis

January 2014

Study patients with HIV­­–hepatitis C coinfection progressed to successive degrees of severity of liver fibrosis 9 years sooner than those infected with HCV alone. Further findings from the study suggest that suppressing HIV with antiretroviral medications may slow HCV-related liver fibrosis.

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High Rates of Job Leaving Among Addiction Counselors

April 2012

Substance abuse counselors and clinical supervisors disclosed high job turnover rates in a survey of 27 treatment organizations.

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