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NIDA Notes Articles: Treatment

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Morphine Speeds AIDS Onset in Monkeys

June 2008

Highlights the work of investigators who discovered key ways in which morphine may accelerate the progression of AIDS in animal studies.

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More Convenient Preparations of Buprenorphine Pass Test

July 2012

Soluble-film preparations of buprenorphine suppressed heroin abusers’ withdrawal symptoms with no serious side effects in a recent clinical trial. They dissolved more rapidly in the mouth than the pill form of the medication, providing faster relief.

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Modafinil Normalizes Sleep During Early Cocaine Abstinence

December 2010
Describes a study investigating the effectiveness of modafinil in enhancing sleep among cocaine abusers who are currently abstinent.

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Microneedle Milestone: One Week of Transdermal Drug Delivery

March 2014

Microneedles are an innovative technique for delivering medications through the skin, a route that could particularly benefit patients receiving naltrexone therapy for opioid and alcohol dependence. Researchers have found a way to use the transdermal technique to deliver a single treatment of naltrexone that lasts for 7 days.

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Methamphetamine Abuse Undermines Dental Health

July 2011
Describes research that sheds light on the correlation between increased dental disease and methamphetamine abuse.

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Methadone Therapy in Prison Benefits Men a Year Out

November 2009

Describes clinical trial results providing evidence that methadone maintenance to men in prison can pay off in better retention in community treatment and reduced drug abuse following their release.

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Methadone Reduces Rats' Cocaine Seeking

December 2008

Reports on an animal study showing that methadone, normally used as a therapy for opioid abuse, may prove to be an effective treatment for cocaine abuse.

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Medications That Treat Opioid Addiction Do Not Impair Liver Health

December 2013

A trial of buprenorphine/naloxone (Bup/Nx) showed no evidence that the medicine was associated with liver damage. The drug gave results similar to those of methadone. The study data indicate that although most patients can be treated safely with either methadone or Bup/Nx without major concern for liver injury, clinicians are advised to continue to monitor the liver health of their patients who are on methadone or Bup/Nx therapy.

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Medications That Normalize Brain Glutamate Reduce Drug-Seeking in Rats

October 2010
Reports on two studies that demonstrate the promise of treating addiction with medications that alleviate drug-induced alterations in signaling by the neurotransmitter glutamate.

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Medication Reduces Rats' Return to Methamphetamine Seeking

July 2011

Reports on a new medication strategy under investigated in animal studies that shows promise for preventing relapse to drug abuse.

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