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NIDA Notes Articles: Naltrexone

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Two NIDA Grantees Receive Sarnat Prize

March 2011
Announces the recipients of the 2010 Rhoda and Bernard Sarnat International Prize in Mental Health, Dr. Eric J. Nestler and Dr. Charles P. O'Brien, prominent addiction scientists.

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Naltrexone via Skin Patch Proves Effectiveness of New Technology

November 2009

Reports on a new device that creates tiny painless punctures in the skin to allow medication to flow evenly from a skin patch into dermal capillaries and the bloodstream.

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Naltrexone Implant Outperforms Daily Pill in Russian Trial

November 2013

More than half of heroin-addicted patients treated with naltrexone via an implanted delivery device maintained abstinence throughout a 6-month clinical trial in Saint Petersburg, Russia. The implant device, which releases a steady dose of naltrexone continuously for 2 months, averted relapse to heroin use three times as effectively as daily oral doses of the medication.

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Microneedle Milestone: One Week of Transdermal Drug Delivery

March 2014

Microneedles are an innovative technique for delivering medications through the skin, a route that could particularly benefit patients receiving naltrexone therapy for opioid and alcohol dependence. Researchers have found a way to use the transdermal technique to deliver a single treatment of naltrexone that lasts for 7 days.

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Lofexidine May Enhance Naltrexone Efficacy

December 2008

Highlights results from a pilot study suggesting that lofexidine, an anti-hypertensive medication, can enhance success rates among patients taking maintenance naltrexone to avoid opioid relapse.

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Dr. Charles O’Brien Receives the James B. Isaacson Award for Lifetime Achievement

November 2012

NIDA researcher Dr. Charles O’Brien recently received the James B. Isaacson Award for a lifetime of research on the biological basis of alcoholism.

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Detoxification Services and Pharmacotherapies Lacking in Nation's Jails and Prisons

December 2010

Reports findings from a survey that revealed that although substance abuse is prevalent in jails and prisons, many correctional facilities do not offer detoxification services or therapies to aid in maintaining abstinence.

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Combined Treatments Improve Dual Abstinence

October 2009

Reports on a study investigating the effectiveness of a combined therapy of disulfiram and naltrexone for people who abuse cocaine and alcohol.

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American Researcher Dr. Charles O’Brien Knighted by French Government

January 2014

NIDA grantee Dr. O’Brien was honored for his “exemplary personal commitment to French‒American relations as symbolized by … exceptional cooperation in science and in public health.”

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