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NIDA Notes Articles: Opioids
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First-time Patients Opt for Office-Based Buprenorphine

October 2006
Presents highlights of a study suggesting that compared with methadone, office-based buprenorphine treatment attracts individuals who have less extensive addiction histories.
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Incentives Reduce Stimulant Abuse During Methadone Maintenance

April 2007
Summarizes a study on the use of incentives to encourage abstinence among methadone maintenance patients in outpatient programs.

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Lofexidine May Enhance Naltrexone Efficacy

December 2008

Highlights results from a pilot study suggesting that lofexidine, an anti-hypertensive medication, can enhance success rates among patients taking maintenance naltrexone to avoid opioid relapse.
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Medications That Normalize Brain Glutamate Reduce Drug-Seeking in Rats

October 2010
Reports on two studies that demonstrate the promise of treating addiction with medications that alleviate drug-induced alterations in signaling by the neurotransmitter glutamate.
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Meeting Reviews Progress On Prescription Opioid Misuse

April 2007
Describes a meeting of researchers and clinicians who gathered to discuss the challenges in balancing appropriate pain treatment with efforts to minimize prescription opioid misuse.

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Methadone Reduces Rats' Cocaine Seeking

December 2008

Reports on an animal study showing that methadone, normally used as a therapy for opioid abuse, may prove to be an effective treatment for cocaine abuse.
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Methadone Therapy in Prison Benefits Men a Year Out

November 2009

Describes clinical trial results providing evidence that methadone maintenance to men in prison can pay off in better retention in community treatment and reduced drug abuse following their release.
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More Convenient Preparations of Buprenorphine Pass Test

July 2012
Soluble-film preparations of buprenorphine suppressed heroin abusers’ withdrawal symptoms with no serious side effects in a recent clinical trial. They dissolved more rapidly in the mouth than the pill form of the medication, providing faster relief.
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Naltrexone via Skin Patch Proves Effectiveness of New Technology

November 2009

Reports on a new device that creates tiny painless punctures in the skin to allow medication to flow evenly from a skin patch into dermal capillaries and the bloodstream.
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Not All Mesolimbic Dopamine Neurons Are Alike

March 2008
Reports on research showing that the neurons that deliver dopamine to two regions of the brain's mesolimbic reward system respond differently to opioids, an important finding for drug treatment research.

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