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NIDA Notes Articles: Tobacco

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In Animals, Receptor Puts Brakes on Nicotine Consumption

March 2012

New research suggests that differences in tobacco consumption reflect, in part, differences in the functional efficacy of a specific type of receptor in a pathway of the brain. In animal studies, nicotinic acetylcholine receptors with the α5 subunit played a key role in producing aversive responses to nicotine, thereby dissuading further consumption of the drug.

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Financial Strain Hinders Smoking Cessation

December 2011

Helping smokers deal with financial problems could improve their chances of staying abstinent after receiving treatment, according to a new study. Participants with the most financial strain had the least success in remaining abstinent.

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Program Helps Troubled Boys Reduce Substance Abuse

December 2011

Chronically delinquent boys in Multidimensional Treatment Foster Care reduced their substance abuse more than boys assigned to Community Group Care.

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Individual Differences in Decisionmaking Style May Predict Teen Problems

December 2011

Reports on the relative influence of genes versus environment on adolescents’ choices that involve delayed gratification.

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Nanotechnology Powers Smart Skin Patch

November 2011

An in vitro test demonstrates the potential of a programmable skin patch that will enable physicians to tailor transdermal medication doses to match patients' fluctuating needs.

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Resting Brain Studies Shed New Light on Vulnerabilities

November 2011

Individuals with weak signaling in a nicotine-sensitive brain circuit were more vulnerable to nicotine dependence than those with stronger signaling, according to a study conducted while the subjects’ brains were in a resting state. A second resting-state study finds that the same circuit appears to mediate dependence associated with a genetic risk factor for smoking.

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Gene Influences Impact of Maternal Smoking on Children's Behavioral Problems

July 2011
Describes research showing that the combination of prenatal smoking exposure and specific genes increases children’s and adolescent’s risk for behavior problems.

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Menthol May Strengthen Nicotine Addiction

March 2011
Reports on a study of Latino and African-American smokers of menthol cigarettes who did not benefit as much from a month-long smoking cessation program as smokers of non-menthol cigarettes.

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Fewer Girls Are Smoking, But Change Is Uneven

March 2011

Reports 2010 rates of cigarette smoking among eighth girls, providing historical data and racial and ethnic differences.

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Prevention Program Averts Initiation of Alcohol and Tobacco Use

March 2011
Describes a community focused prevention program that aids towns in lowering rates of delinquency, initiation of alcohol and tobacco use, and binge drinking among middle school students.

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