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NIDA Notes Articles: Tobacco

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Studies Link Family of Genes to Nicotine Addiction

December 2009

Reports study results suggesting that genes for several acetylcholine receptor proteins influence early smoking responses and the likelihood of nicotine dependence.

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Stimulus Money Will Fund a Surge in Knowledge

April 2009

Describes NIDA’s drug abuse and addiction research priorities for the use of the American Recovery and Reinvestment Act of 2009 funds.

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Standard Treatments Help Depressed Smokers Quit

April 2007
Describes a study comparing Staged Care Intervention, a combination treatment for smoking cessation, among smokers in outpatient treatment for depression and a control group.

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Smoking Cessation Does Not Interfere With Recovery From Substance Use

October 2014

Despite common concerns that encouraging patients to quit smoking might endanger their success in treatment of substance use and mood or anxiety disorders, smoking cessation appears unlikely to hinder and may even help recovery.

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Smoking and Drinking Continue to Decline, But Marijuana Stalls in Latest MTF Survey

October 2009

Highlights trends from a 2008 survey of teenage substance abuse, cigarette smoking and alcohol use and discusses the implications of these changing data.

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Smokers Who Quit May Have Genetic Advantage

November 2009

Describes research providing evidence that genes may influence how successful a person is in quitting smoking and which cessation technique may work best for them.

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Sensory Aspects of Smoking May Counter Bad Mood, Craving

October 2009

Describes study findings revealing that the act of smoking, apart from actual or expected nicotine delivery, may soothe a smoker's negative mood.

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Resting Brain Studies Shed New Light on Vulnerabilities

November 2011

Individuals with weak signaling in a nicotine-sensitive brain circuit were more vulnerable to nicotine dependence than those with stronger signaling, according to a study conducted while the subjects’ brains were in a resting state. A second resting-state study finds that the same circuit appears to mediate dependence associated with a genetic risk factor for smoking.

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Research Focuses on Groups With High Smoking Rates

April 2012
Dr. Volkow discusses NIDA’s efforts to develop effective antismoking treatments for populations with persistently high rates of smoking, such as people with psychiatric disorders, high school dropouts, and Native Americans.

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Receptor May Underlie Gender Differences in Response to Smoking Cessation

May 2013

Men benefit more than women from nicotine replacement therapy for smoking cessation because nicotine affects a key neuroreceptor differently in the two sexes, a NIDA-sponsored study suggests. The findings highlight the need for alternative therapies for women smokers, and point to the female hormone progesterone as a potential therapeutic target.

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