Describes a study showing that cocaine, which increases dopamine levels, also can tap into an intracellular dopamine reserve pool.
March 2008 Reports on research of chronic cocaine abusers who may feel they are sleeping better during early abstinence revealed that the opposite may be true.
October 2007 Reports on two studies indicating that orexin, a neuropeptide that stimulates eating and regulates wakefulness, also fosters animals' drug seeking and craving responses to drugs.
Reports on the work of addiction researchers who are learning how acute and chronic cocaine exposure regulates certain genes, based on knowledge from developmental and cancer biology.
Discusses the central importance of studying drugs' effects on neurotransmission and describes some of the most common experimental methods used in this research.
April 2007 Reports on data that reviewing the benefits of addiction treatment among abstinent men as compared with those who continued to abuse cocaine.
April 2007 Describes investigations to advance the development of potential drug abuse relapse prevention agents by targeting specific receptors of the neurochemical serotonin.
February 2007 Describes evidence supporting the view that developmental differences in brain systems that use the neurotransmitter dopamine underlie age differences in susceptibility to drug abuse.
February 2007 Summarizes an animal study of the neural changes in the amygdala portion of the brain that occur as a result of cocaine exposure followed by withdrawal of the drug.
February 2007 Reports on the work of researchers who used brain images to correlate cocaine-addicted patients' regional brain responses to drug cues with their outcomes in subsequent treatment.