Reports on a study involving researchers who successfully desensitized mice to cocaine by genetically altering their dopamine transporters.
March 2008 Summarizes research on the effects of long-term regular cocaine abuse on the cardiovascular system in African Americans.
Describes a study showing that cocaine, which increases dopamine levels, also can tap into an intracellular dopamine reserve pool.
March 2008 Reports on research of chronic cocaine abusers who may feel they are sleeping better during early abstinence revealed that the opposite may be true.
Discusses the central importance of studying drugs' effects on neurotransmission and describes some of the most common experimental methods used in this research.
October 2007 Reports on two studies indicating that orexin, a neuropeptide that stimulates eating and regulates wakefulness, also fosters animals' drug seeking and craving responses to drugs.
Reports on the work of addiction researchers who are learning how acute and chronic cocaine exposure regulates certain genes, based on knowledge from developmental and cancer biology.
April 2007 Reports on data that reviewing the benefits of addiction treatment among abstinent men as compared with those who continued to abuse cocaine.
April 2007 Describes investigations to advance the development of potential drug abuse relapse prevention agents by targeting specific receptors of the neurochemical serotonin.
February 2007 Discusses the work of NIDA’s Division of Basic Neuroscience and Behavioral Research, the Institute’s locus for studies into the fundamental brain mechanisms underlying drug abuse and addiction.