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NIDA Notes Articles: Cocaine

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Fewer Young Adults Abuse Cocaine and Methamphetamine, National Survey Finds

December 2008

Reports prevalence rates of illicit drug abuse among youths and young adults based on 2007 data from a national survey of drug use and health.

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Gene Experiment Confirms a Suspected Cocaine Action

October 2007

Reports on the work of addiction researchers who are learning how acute and chronic cocaine exposure regulates certain genes, based on knowledge from developmental and cancer biology.

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High Rates of Illegal Drug Use Among Alcohol-Dependent Adults

July 2011
Highlights data on the prevalence of rates of illegal drug use and nonmedical use of prescription drugs among adults dependant on alcohol, as compared with the general population.

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How Drug Abuse Affects the Brain and Alters Behavior Are Key Questions Driving Division's Work

February 2007
Discusses the work of NIDA’s Division of Basic Neuroscience and Behavioral Research, the Institute’s locus for studies into the fundamental brain mechanisms underlying drug abuse and addiction.

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Impacts of Drugs on Neurotransmission

October 2007

Discusses the central importance of studying drugs' effects on neurotransmission and describes some of the most common experimental methods used in this research.

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Intervention Strengthens American Indian Teen Mothers’ Parenting

February 2014

Teen mothers on three American Indian reservations improved on several measures of parenting after participating in Family Spirit, a home-visiting intervention developed with NIDA support. At 12 months postpartum, the women’s children exhibited reduced rates of emotional difficulties predicting later drug abuse and other behavioral problems. Infants at highest risk—those whose mothers had histories of drug abuse—benefited the most.

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Long-Term Cocaine Abuse Linked With Impaired Heart Function

March 2008
Summarizes research on the effects of long-term regular cocaine abuse on the cardiovascular system in African Americans.

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Long-Term Cocaine Self-Administration Depresses Brain Activity

December 2008

Discusses research exploring how widespread the reduction of neural activity is in the brain with chronic exposure to cocaine.

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Low Dopamine Receptor Availability May Promote Cocaine Addiction

April 2009

Describes findings from an animal study showing that cocaine lowers availability of dopamine receptors in the basal ganglia, an area of the brain that includes portions of the reward system.

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Male Rats’ Cocaine Exposure Affects Their Offspring’s Drug Responses

August 2013

In a surprising finding, male rats who used cocaine sired male offspring who later exhibited blunted responses to the drug. Researchers determined the cause was an epigenetic alteration.

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