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NIDA Notes Articles: Cocaine

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Neuropeptide Promotes Behaviors Tied to Addiction and Overeating

July 2011

Reports on several studies implicating a certain neuropeptide (a signaling molecule) in fostering addition and overeating and discusses implications for addiction treatment.

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High Rates of Illegal Drug Use Among Alcohol-Dependent Adults

July 2011
Highlights data on the prevalence of rates of illegal drug use and nonmedical use of prescription drugs among adults dependant on alcohol, as compared with the general population.

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Dr. Paul Kenny Receives the 2010 Waletzky Memorial Award

March 2011
Announces the recipient of a 2010 award for innovation in research on drug addiction and alcoholism and describes his work on increasing our understanding of the molecular foundation of addiction.

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Deep Brain Stimulation Reduces Rats' Cocaine Seeking

December 2010
Describes results from an animal study involving deep brain stimulation that holds promise as a therapy for severe cocaine addiction.

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Drug Abuse at Highest Level in Nearly a Decade

December 2010

Reports on 2009 data indicating a rise in drug abuse in the United States and the factors that may have contributed to this increase.

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Cocaine Vaccine Helps Some Reduce Drug Abuse

December 2010

Reports on the results of a clinical trial that tested the effectiveness of a cocaine vaccine designed as a therapy for cocaine abuse and plans underway for a new study of 300 patients to confirm these results.

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Modafinil Normalizes Sleep During Early Cocaine Abstinence

December 2010
Describes a study investigating the effectiveness of modafinil in enhancing sleep among cocaine abusers who are currently abstinent.

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Crack Cocaine Promotes Progression of HIV Infection to AIDS

October 2010
Reports on two studies showing a high prevalence of HIV infection and more rapid progression to disability and death among drug abusers.

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Medications That Normalize Brain Glutamate Reduce Drug-Seeking in Rats

October 2010
Reports on two studies that demonstrate the promise of treating addiction with medications that alleviate drug-induced alterations in signaling by the neurotransmitter glutamate.

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Brain Opioid Receptor Levels Predict Time to Cocaine Relapse

October 2010
Describes study findings revealing that cocaine abusers who maintain high levels of a certain receptor in their brain during early abstinence relapse sooner than abusers whose levels drop.

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