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NIDA Notes Articles: Treatment Research

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Attention to Bipolar Disorder Strengthens Substance Abuse Treatment

April 2010

Describes a study of participants who had both substance abuse and bipolar disorder to investigate the potential benefits of integrated group therapy for this population.

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Basic Science Discoveries Yield Novel Approaches to Analgesia

September 2008

Describes research to develop new compounds that match or exceed the pain relief provided by opioids while avoiding their shortcomings.

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Brain Mechanism Turns Off Cocaine-Related Memory in Rats

October 2006
Describes a series of experiments that have added to evidence that a brain enzyme controls key memory processes that link drug experiences, the surroundings in which they take place, and the urge to repeat them.

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Brain Responds to Marijuana Cues in Familiar Manner

March 2011
Researchers found that the brain activity that takes place when cues trigger marijuana cravings is similar to the activity that accompanies cravings for other drugs.

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Brief Intervention Helps Adolescents Curb Substance Use

January 2013

NIDA-funded researchers have gathered evidence that brief interventions can help adolescents move away from drug use. In a clinical trial, middle and high school students markedly reduced their substance use following two 60-minute sessions that combined motivational interviewing and cognitive behavioral therapy.

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Buprenorphine During Pregnancy Reduces Neonate Distress

July 2012

Sublingual buprenorphine is a safe and effective alternative to methadone for treating opioid dependence during pregnancy, finds the Maternal Opioid Treatment: Human Experimental Research (MOTHER) study, a NIDA-supported clinical trial. Women who received either medication had similar pregnancy and birth outcomes, but infants born to women who received buprenorphine had milder symptoms of neonatal opioid withdrawal.

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Buprenorphine Plus Behavioral Therapy Is Effective For Adolescents With Opioid Addiction

October 2006
Reports on a study of adolescents addicted to opioids who responded better to buprenorphine than clonidine in a clinical trial in which all patients also received behavioral therapy.

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Bupropion Reduces Meth's Subjective Effects and Cue-Induced Craving

March 2008

Describes a study investigating the use of the antidepressant bupropion as a potential therapy for methamphetamine addiction.

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California Reaped Large Savings by Diverting Drug-Using Offenders Into Treatment

February 2014

California’s Proposition 36, which allows qualified drug offenders to enter substance use treatment rather than go to jail or prison, saved the state close to $100 million in its first year.

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Cocaine Abusers' Pretreatment Cue Responses Predict Recovery Success

February 2007
Reports on the work of researchers who used brain images to correlate cocaine-addicted patients' regional brain responses to drug cues with their outcomes in subsequent treatment.

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