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NIDA Notes Articles: Treatment Research

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A Rapid Teen Substance Use Screening Tool for Clinicians

July 2015

Answers to three simple questions can help a busy health care provider flag a teen’s problematic use of alcohol, tobacco, or marijuana.

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Abstinent Smokers' Nicotinic Receptors Take More Than a Month to Normalize

October 2009

Describes research revealing that for up to 6 weeks after smokers quit, their brain cells have more nicotine-binding receptors than nonsmokers, which may explain the struggle to quit.

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Addiction Science Award Winners Announced

December 2010
Announces the 2010 high school student recipients of the Addiction Science Awards and describes their winning addiction-focused projects.

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Alleviation of Post-traumatic Stress Disorder May Improve Addiction Treatment

April 2012

Women with post-traumatic stress disorder (PTSD) who abused drugs responded better to substance abuse treatment after their PTSD symptoms improved, according to a recent study, which also found that reductions in substance abuse did not ease PTSD severity

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Animal Research Advances Effort to Develop Vaccines Against Cocaine, Heroin Abuse

September 2012

New vaccines that aim to promote recovery from cocaine and heroin abuse showed promise in animal testing. Both vaccines induced rats’ immune system to produce high titers of antibodies that inhibit the target drug from reaching the brain. The rats’ behaviors when given access to the target drug indicated that the vaccines reduced the reinforcing effects that, in recovering people, can cause lapses to turn into relapses.

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Animation: Building an Anti-Drug Vaccine

December 2012

The immune system has an extraordinary ability to recognize compounds foreign to the body and eliminate them. NIDA-sponsored scientists are working to harness this ability to create vaccines that will protect individuals against the psychogenic and addictive effects of abused drugs. This animation shows one of the most promising strategies, which has already yielded partial success in producing effective vaccines against nicotine, cocaine, and other drugs.

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Antibody Fragment Removes Methamphetamine From the Brain

November 2009

Reports animal study findings on development of an antibody fragment that rapidly removes methamphetamine from the brain and discusses implications for treatment of overdose.

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Anticipation of Methadone Enhances Brain Reactivity to Heroin Cues

December 2009

Describes findings of a study revealing that images of heroin preparation and injection can incite craving and excite brain areas associated with reward-seeking even in methadone-maintained patients.

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Antipsychotic Drug Prevents Morphine Tolerance in Mice

April 2007

Summarizes animal studies indicating that an antipsychotic drug, trifluoperazine, prevents morphine tolerance in mice.

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Antiretroviral Treatment Reduces Spread of HIV Among Injection Drug Users

April 2012

Expanded use of antiretroviral therapy in British Columbia reduced the spread of HIV among injection drug users and others in the province.


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