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NIDA Notes Articles: Treatment Research

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Buprenorphine During Pregnancy Reduces Neonate Distress

July 2012

Sublingual buprenorphine is a safe and effective alternative to methadone for treating opioid dependence during pregnancy, finds the Maternal Opioid Treatment: Human Experimental Research (MOTHER) study, a NIDA-supported clinical trial. Women who received either medication had similar pregnancy and birth outcomes, but infants born to women who received buprenorphine had milder symptoms of neonatal opioid withdrawal.

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Brief Intervention Helps Adolescents Curb Substance Use

January 2013

NIDA-funded researchers have gathered evidence that brief interventions can help adolescents move away from drug use. In a clinical trial, middle and high school students markedly reduced their substance use following two 60-minute sessions that combined motivational interviewing and cognitive behavioral therapy.

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Brain Responds to Marijuana Cues in Familiar Manner

March 2011
Researchers found that the brain activity that takes place when cues trigger marijuana cravings is similar to the activity that accompanies cravings for other drugs.

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Brain Mechanism Turns Off Cocaine-Related Memory in Rats

October 2006
Describes a series of experiments that have added to evidence that a brain enzyme controls key memory processes that link drug experiences, the surroundings in which they take place, and the urge to repeat them.

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Basic Science Discoveries Yield Novel Approaches to Analgesia

September 2008

Describes research to develop new compounds that match or exceed the pain relief provided by opioids while avoiding their shortcomings.

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Attention to Bipolar Disorder Strengthens Substance Abuse Treatment

April 2010

Describes a study of participants who had both substance abuse and bipolar disorder to investigate the potential benefits of integrated group therapy for this population.

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Aripiprazole Prevents Rats From Resuming Cocaine Seeking

December 2008

Reports on study results indicating a medication prescribed for schizophrenia and manic phases of bipolar disorder shows promise as a cocaine addiction treatment.

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Antiretroviral Treatment Reduces Spread of HIV Among Injection Drug Users

April 2012
Expanded use of antiretroviral therapy in British Columbia reduced the spread of HIV among injection drug users and others in the province.

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Antipsychotic Drug Prevents Morphine Tolerance in Mice

April 2007
Summarizes animal studies indicating that an antipsychotic drug, trifluoperazine, prevents morphine tolerance in mice.

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Anticipation of Methadone Enhances Brain Reactivity to Heroin Cues

December 2009

Describes findings of a study revealing that images of heroin preparation and injection can incite craving and excite brain areas associated with reward-seeking even in methadone-maintained patients.

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