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NIDA Notes Articles: Treatment Research

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Combined Treatments Improve Dual Abstinence

October 2009

Reports on a study investigating the effectiveness of a combined therapy of disulfiram and naltrexone for people who abuse cocaine and alcohol.

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Combination Treatment Extends Marijuana Abstinence

March 2008
Describes research investigating the use of a treatment that combines vouchers and cognitive behavioral therapy as compared with the use of either treatment alone for marijuana abuse.

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Combination Therapy Most Effective for Helping Smokers Quit

March 2011

Examines results from a randomized clinical trial which found that treatment with a nicotine patch and nicotine lozenge together produced the greatest benefits in helping people quit smoking and remain abstinent.

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Cognitive Strategy Reduces Craving by Altering Brain Activity

April 2012

While viewing images of cigarettes, smokers reported milder cravings when they shifted their focus from the pleasures of smoking to its harmful effects. Brain imaging showed a correlation between the reductions in craving and altered activity levels in regions associated with emotional regulation and reward.

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Cocaine Vaccine Helps Some Reduce Drug Abuse

December 2010

Reports on the results of a clinical trial that tested the effectiveness of a cocaine vaccine designed as a therapy for cocaine abuse and plans underway for a new study of 300 patients to confirm these results.

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Cocaine Locks Rats Into Unrewarding Behaviors

April 2009

Describes research with rats to better understand cocaine’s effect on the neural signaling in the learning circuits of the brain.

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Cocaine Abusers' Pretreatment Cue Responses Predict Recovery Success

February 2007
Reports on the work of researchers who used brain images to correlate cocaine-addicted patients' regional brain responses to drug cues with their outcomes in subsequent treatment.

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California Reaped Large Savings by Diverting Drug-Using Offenders Into Treatment

February 2014

California’s Proposition 36, which allows qualified drug offenders to enter substance use treatment rather than go to jail or prison, saved the state close to $100 million in its first year.

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Bupropion Reduces Meth's Subjective Effects and Cue-Induced Craving

March 2008

Describes a study investigating the use of the antidepressant bupropion as a potential therapy for methamphetamine addiction.

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Buprenorphine Plus Behavioral Therapy Is Effective For Adolescents With Opioid Addiction

October 2006
Reports on a study of adolescents addicted to opioids who responded better to buprenorphine than clonidine in a clinical trial in which all patients also received behavioral therapy.

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