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NIDA Notes Articles: Relapse and Recovery

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Drug Cues Outside Awareness Rapidly Trigger Brain's Emotion Centers

October 2009

Describes research showing that cocaine abusers appear to have a rapid neural response to reward cues outside of their awareness, possibly signifying vulnerability to relapse.

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Abstinent Smokers' Nicotinic Receptors Take More Than a Month to Normalize

October 2009

Describes research revealing that for up to 6 weeks after smokers quit, their brain cells have more nicotine-binding receptors than nonsmokers, which may explain the struggle to quit.

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Cocaine Locks Rats Into Unrewarding Behaviors

April 2009

Describes research with rats to better understand cocaine’s effect on the neural signaling in the learning circuits of the brain.

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Aripiprazole Prevents Rats From Resuming Cocaine Seeking

December 2008

Reports on study results indicating a medication prescribed for schizophrenia and manic phases of bipolar disorder shows promise as a cocaine addiction treatment.

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New Vaccines Are Being Developed Against Addiction and Relapse

December 2008

Highlights NIDA-funded research to develop vaccines against addiction to drugs such as cocaine, nicotine, phencyclidine (PCP), and methamphetamine.

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High-Risk Drug Offenders Do Better With Close Judicial Supervision

December 2008

Reports on research showing that increasing the mandatory drug court monitoring sessions for high-risk drug offenders can enhance program success rates.

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Lofexidine May Enhance Naltrexone Efficacy

December 2008

Highlights results from a pilot study suggesting that lofexidine, an anti-hypertensive medication, can enhance success rates among patients taking maintenance naltrexone to avoid opioid relapse.

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Social Neuroscience Meeting Aims To Improve Prevention, Treatment

June 2008

Presents highlights of a meeting of scientists and clinicians to review research results from the field of social neuroscience, the study of how neurobiology and the social environment interact.

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New Therapy Reduces Drug Abuse Among Patients With Severe Mental Illness

June 2008

Describes a new intervention that enhances recovery prospects for substance abusers whose mental illness complicates the path toward recovery.

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Combination Treatment Extends Marijuana Abstinence

March 2008
Describes research investigating the use of a treatment that combines vouchers and cognitive behavioral therapy as compared with the use of either treatment alone for marijuana abuse.

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