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NIDA Notes Articles: Relapse and Recovery
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Young Opioid Abusers Benefit From Extended Buprenorphine-Naloxone Treatment

April 2010
Reports on a study investigating the benefits of extended opioid maintenance therapy that included drug counseling and 12 weeks of therapy with buprenorphine and naloxone.
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Anticipation of Methadone Enhances Brain Reactivity to Heroin Cues

December 2009

Describes findings of a study revealing that images of heroin preparation and injection can incite craving and excite brain areas associated with reward-seeking even in methadone-maintained patients.
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Test Substance Attenuates Signs of Cocaine Withdrawal in Rats

December 2009

Reports on several drugs that may ward off depression and anxiety, common withdrawal symptoms from cocaine, based on an animal study.
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Rare Glutamate Receptor Proliferates After Cocaine Withdrawal

December 2009

Reports findings that a rare neuroreceptor may be linked to the intensive cravings cocaine abusers experience during their first weeks of abstinence.
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Report Discusses Co-Occurrence of Drug Abuse and Other Mental Disorders

December 2009

Describes an updated report on the co-occurrence, or comorbidity, of substance use disorders and other psychiatric disorders such as ADHD, schizophrenia, and depression.
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Recovery Checkup System Helps Substance Abusers Who Have Mental Disorders

December 2009

Reports on a posttreatment intervention to support recovery that may be especially beneficial for substance abusers with co-occurring mental disorders.
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Recovery May Be Harder for Adolescents, Animal Study Suggests

December 2009

Reports animal study findings that suggest adolescents' heightened sensitivity to drug reward puts them at enhanced risk of addiction and may also increase their challenges in recovery.
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Methadone Therapy in Prison Benefits Men a Year Out

November 2009

Describes clinical trial results providing evidence that methadone maintenance to men in prison can pay off in better retention in community treatment and reduced drug abuse following their release.
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Combined Treatments Improve Dual Abstinence

October 2009

Reports on a study investigating the effectiveness of a combined therapy of disulfiram and naltrexone for people who abuse cocaine and alcohol.
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Drug Cues Outside Awareness Rapidly Trigger Brain's Emotion Centers

October 2009

Describes research showing that cocaine abusers appear to have a rapid neural response to reward cues outside of their awareness, possibly signifying vulnerability to relapse.

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