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NIDA Notes Articles: Medication Development

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More Convenient Preparations of Buprenorphine Pass Test

July 2012

Soluble-film preparations of buprenorphine suppressed heroin abusers’ withdrawal symptoms with no serious side effects in a recent clinical trial. They dissolved more rapidly in the mouth than the pill form of the medication, providing faster relief.

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Buprenorphine During Pregnancy Reduces Neonate Distress

July 2012

Sublingual buprenorphine is a safe and effective alternative to methadone for treating opioid dependence during pregnancy, finds the Maternal Opioid Treatment: Human Experimental Research (MOTHER) study, a NIDA-supported clinical trial. Women who received either medication had similar pregnancy and birth outcomes, but infants born to women who received buprenorphine had milder symptoms of neonatal opioid withdrawal.

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Well-Known Mechanism Underlies Benzodiazepines' Addictive Properties

April 2012
New research establishes that benzodiazepines cause addiction in a way similar to that of opioids, cannabinoids, and the club drug GHB. The discovery opens the door to designing new benzodiazepines that counteract anxiety but are not addictive.

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NIDA Announces Avant-Garde Medication Development Awards

March 2012
Dr. Thomas Kosten of Baylor College of Medicine and Dr. Peter Burkhard of the University of Connecticut are the recipients of NIDA’s 2011 Avant-Garde Awards for Innovative Medication Development Research. Dr. Kosten is developing a vaccine against methamphetamine abuse and Dr. Burkhard is developing a vaccine to counter nicotine addiction.

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In Animals, Receptor Puts Brakes on Nicotine Consumption

March 2012

New research suggests that differences in tobacco consumption reflect, in part, differences in the functional efficacy of a specific type of receptor in a pathway of the brain. In animal studies, nicotinic acetylcholine receptors with the α5 subunit played a key role in producing aversive responses to nicotine, thereby dissuading further consumption of the drug.

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Neuropeptide Promotes Behaviors Tied to Addiction and Overeating

July 2011

Reports on several studies implicating a certain neuropeptide (a signaling molecule) in fostering addition and overeating and discusses implications for addiction treatment.

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Medication Reduces Rats' Return to Methamphetamine Seeking

July 2011

Reports on a new medication strategy under investigated in animal studies that shows promise for preventing relapse to drug abuse.

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NIDA Appoints New Director of the Intramural Research Program

December 2010
Announces NIDA’s new director of its intramural research program, Antonello Bonci, M.D., a leading researcher in neuropsychopharmacology.

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Modafinil Normalizes Sleep During Early Cocaine Abstinence

December 2010
Describes a study investigating the effectiveness of modafinil in enhancing sleep among cocaine abusers who are currently abstinent.

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Cocaine Vaccine Helps Some Reduce Drug Abuse

December 2010

Reports on the results of a clinical trial that tested the effectiveness of a cocaine vaccine designed as a therapy for cocaine abuse and plans underway for a new study of 300 patients to confirm these results.

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