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NIDA Notes Articles: Research Briefs

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Exposure to Morphine During Early Adolescence Sensitizes Rats as Adults (October 2007)

Presents highlights of a study indicating that exposure to morphine during adolescence may increase sensitivity to the drug during adulthood.

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Naltrexone-Nicotine Patch Combination Shows Promise (April 2007)

Reports findings from a clinical trial investigating the effectiveness of naltrexone as a supplement to nicotine replacement therapy for smoking cessation.

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Scientists Pinpoint Brain's Sweet Tooth (April 2007)

Reports on research that successfully traced rats’ liking for sweets to a 1-cubic millimeter site in the medial shell of the nucleus accumbens in the brain.

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Antipsychotic Drug Prevents Morphine Tolerance in Mice (April 2007)

Summarizes animal studies indicating that an antipsychotic drug, trifluoperazine, prevents morphine tolerance in mice.

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Incentives Reduce Stimulant Abuse During Methadone Maintenance (April 2007)

Summarizes a study on the use of incentives to encourage abstinence among methadone maintenance patients in outpatient programs.

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Medical Care During Addiction Treatment Reduces Hospital Use (February 2007)

Reports on an analysis comparing three types of addiction treatment programs: methadone maintenance programs, long-term residential programs, and nonmethadone programs.

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Brain Changes Accompany Cocaine Withdrawal (February 2007)

Summarizes an animal study of the neural changes in the amygdala portion of the brain that occur as a result of cocaine exposure followed by withdrawal of the drug.

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Studies Focus on Acculturation and Hispanic Youth (February 2007)

Summarizes a study that analyzes factors associated with the risk of drug addiction among 19- to 21-year-old Hispanic women born in the United States as compared with immigrants.

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Stress Response May Underlie African- Americans' Reduced Pain Tolerance (October 2006)

Summarizes research suggesting a physiological difference as the explanation for African-Americans' reported low tolerance for pain.

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Methylphenidate for Comorbid Cocaine Abuse, ADHD (October 2006)

Describes an inpatient study investigating the effectiveness of sustained-release methylphenidate as a treatment for cocaine-addiction patients with ADHD.

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