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NIDA Notes Articles: Featured Articles

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Alcohol Abuse Makes Prescription Drug Abuse More Likely

March 2008
Reports on results from a study showing that men and women with alcohol use disorders are more likely to report nonmedical use of prescription drugs than people who don't drink at all.

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Not All Mesolimbic Dopamine Neurons Are Alike

March 2008
Reports on research showing that the neurons that deliver dopamine to two regions of the brain's mesolimbic reward system respond differently to opioids, an important finding for drug treatment research.

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Impacts of Drugs on Neurotransmission

October 2007
Discusses the central importance of studying drugs' effects on neurotransmission and describes some of the most common experimental methods used in this research.

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Neuropeptide Promotes Drug-Seeking and Craving in Rats

October 2007
Reports on two studies indicating that orexin, a neuropeptide that stimulates eating and regulates wakefulness, also fosters animals' drug seeking and craving responses to drugs.

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Endorphin Derivative Inhibits Reward From Morphine and Nicotine in Rats

October 2007
Describes research investigating a naturally occurring brain chemical that shows early promise as a treatment for addiction in animal studies.

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Study Links Anabolic Steroids to Brain Changes in Adolescent Female Mice

October 2007
Reports on an animal study finding that links anabolic steroids to brain changes in adolescent female mice, changes that can potentially lead to steroid abuse.

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Gene Experiment Confirms a Suspected Cocaine Action

October 2007
Reports on the work of addiction researchers who are learning how acute and chronic cocaine exposure regulates certain genes, based on knowledge from developmental and cancer biology.

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Uneven Regional Brain Development Contributes to Adolescent Risk-Taking

April 2007

Reports on the work of scientists who have linked impulsiveness and risk-taking among adolescents to immaturity of the brain region called the orbitofrontal cortex.

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Interim Methadone Raises Odds of Enrolling in Comprehensive Treatment

April 2007
Reports on a study to investigate the use of methadone maintenance for heroin addicts wait-listed for a treatment program to encourage their likelihood to enroll in the program.

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Vaccine May Reduce Fetal Exposure to Nicotine

April 2007
Describes research on a vaccine developed to facilitate smoking cessation by blocking nicotine penetration into the brain.

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Drugs, Brains, and Behavior - The Science of Addiction

As a result of scientific research, we know that addiction is a disease that affects both brain and behavior.