NIDA Notes Articles: Featured Articles

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Manic Mice Show Heightened Sensitivity to Rewards

October 2009

Reports on an animal study suggesting that the manic stage of bipolar disorder promotes signs of drug abuse vulnerability by enhancing sensitivity to rewards, both natural and drug-related.

Abstinent Smokers' Nicotinic Receptors Take More Than a Month to Normalize

October 2009
Describes research revealing that for up to 6 weeks after smokers quit, their brain cells have more nicotine-binding receptors than nonsmokers, which may explain the struggle to quit.

Program Reduces Girls' Delinquent Behavior

October 2009
Reports on a study involving adolescent girls who were treated for delinquent behaviors in a well-supervised family setting, referred to as Multidimensional Treatment Foster Care.

Ethnic Groups Have Contrasting Genetic Risks for Nicotine Addiction

October 2009
Describes research exploring differences and similarities in the genetic profiles of African-Americans and European-Americans who are heavy smokers.

Methamphetamine Abusers Show Increased Distractibility

April 2009
Highlights findings from a study of former methamphetamine abusers showing evidence of impairment in areas of the brain known to influence cognition, emotion, and decision making.

Cocaine Locks Rats Into Unrewarding Behaviors

April 2009
Describes research with rats to better understand cocaine’s effect on the neural signaling in the learning circuits of the brain.

Prenatal Nicotine Exposure May Damage Receptors That Influence Auditory Processing

April 2009
Reports on a series of animal experiments indicating that nicotine exposure during prenatal fetal development damages a set of receptors in the brain's auditory processing center.

Damage to Brain Area May Immediately Halt Cigarette Addiction

April 2009
Describes a study among people who had sustained brain injuries to investigate whether certain damaged areas of the brain are associated with the ability to quit smoking.

Low Dopamine Receptor Availability May Promote Cocaine Addiction

April 2009
Describes findings from an animal study showing that cocaine lowers availability of dopamine receptors in the basal ganglia, an area of the brain that includes portions of the reward system.

High-Risk Drug Offenders Do Better With Close Judicial Supervision

December 2008
Reports on research showing that increasing the mandatory drug court monitoring sessions for high-risk drug offenders can enhance program success rates.

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Manic Mice Show Heightened Sensitivity to Rewards

Abstinent Smokers' Nicotinic Receptors Take More Than a Month to Normalize

Program Reduces Girls' Delinquent Behavior

Ethnic Groups Have Contrasting Genetic Risks for Nicotine Addiction

Methamphetamine Abusers Show Increased Distractibility

Cocaine Locks Rats Into Unrewarding Behaviors

Prenatal Nicotine Exposure May Damage Receptors That Influence Auditory Processing

Damage to Brain Area May Immediately Halt Cigarette Addiction

Low Dopamine Receptor Availability May Promote Cocaine Addiction

High-Risk Drug Offenders Do Better With Close Judicial Supervision

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Drugs, Brains, and Behavior - The Science of Addiction