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NIDA Notes Articles: Featured Articles

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Uneven Regional Brain Development Contributes to Adolescent Risk-Taking

April 2007

Reports on the work of scientists who have linked impulsiveness and risk-taking among adolescents to immaturity of the brain region called the orbitofrontal cortex.

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Interim Methadone Raises Odds of Enrolling in Comprehensive Treatment

April 2007
Reports on a study to investigate the use of methadone maintenance for heroin addicts wait-listed for a treatment program to encourage their likelihood to enroll in the program.

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Nicotine Alters the Developing Rat Brain

February 2007
Describes animal studies that suggested exposure to the drug during gestation or adolescence may cause lasting alterations in reward and motivation circuits.

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Behavioral Response to Novelty Foreshadows Neurological Response to Cocaine

February 2007
Describes evidence supporting the view that developmental differences in brain systems that use the neurotransmitter dopamine underlie age differences in susceptibility to drug abuse.

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Cocaine Abusers' Pretreatment Cue Responses Predict Recovery Success

February 2007
Reports on the work of researchers who used brain images to correlate cocaine-addicted patients' regional brain responses to drug cues with their outcomes in subsequent treatment.

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Cocaine Craving Activates Brain Reward Structures; Cocaine "High" Dampens Them

February 2007
Reports on a study that documenting changing emotional and neurobiological responses to cocaine with successive doses during a single session of drug taking.

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Buprenorphine Plus Behavioral Therapy Is Effective For Adolescents With Opioid Addiction

October 2006
Reports on a study of adolescents addicted to opioids who responded better to buprenorphine than clonidine in a clinical trial in which all patients also received behavioral therapy.

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Low-Cost Incentives Improve Outcomes in Stimulant Abuse Treatment

October 2006
Reports on a study investigating the use of incentives in the form of prizes to motivate outpatients to stay in behavioral therapy and remain drug free.

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Marijuana Smoking Is Associated With a Spectrum Of Respiratory Disorders

October 2006
Highlights two studies suggesting significant associations between marijuana smoking and respiratory disease.

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Brain Mechanism Turns Off Cocaine-Related Memory in Rats

October 2006
Describes a series of experiments that have added to evidence that a brain enzyme controls key memory processes that link drug experiences, the surroundings in which they take place, and the urge to repeat them.

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Drugs, Brains, and Behavior - The Science of Addiction

As a result of scientific research, we know that addiction is a disease that affects both brain and behavior.