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Your search for Medical Consequences returned 30 results. Search again.

Basic Science

Gene Variants Reduce Opioid Risks

Two recent studies suggest that genotyping may enable clinicians to base therapies on individual patients’ potential responsiveness to opioid drugs’ therapeutic effects and vulnerability to their harmful effects.

Treatment

HIV Infection Accelerates Hepatitis C–Related Liver Fibrosis

Study patients with HIV­­–hepatitis C coinfection progressed to successive degrees of severity of liver fibrosis 9 years sooner than those infected with HCV alone. Further findings from the study suggest that suppressing HIV with antiretroviral medications may slow HCV-related liver fibrosis.

Treatment

Medications That Treat Opioid Addiction Do Not Impair Liver Health

A trial of buprenorphine/naloxone (Bup/Nx) showed no evidence that the medicine was associated with liver damage. The drug gave results similar to those of methadone. The study data indicate that although most patients can be treated safely with either methadone or Bup/Nx without major concern for liver injury, clinicians are advised to continue to monitor the liver health of their patients who are on methadone or Bup/Nx therapy.

Prevention

Prenatal Methamphetamine Exposure Linked With Problems

Study findings indicate that children exposed to methamphetamine prenatally show more signs of increased emotionality, anxiety, and depression than nonexposed children at ages 3 and 5 years.

Treatment

Potential Pain Medication Targets Peripheral Nerves

Researchers report a significant advance in the search for medications that can suppress pain but avoid opioids’ abuse potential and other undesirable CNS effects. A new compound reduces mouse responses in animal models of neurogenic and chronic inflammatory (e.g., arthritic) pain. The compound, called UB937, enhances the natural pain-killing activity of the neurotransmitter anandamide, and exerts its analgesic effects entirely in peripheral tissues, without entering the brain.

Basic Science

Prenatal Cocaine Exposure Increases Monkeys' Impulsivity Into Adulthood

Prenatal drug exposure can have behavioral effects that last well into adulthood, according to two studies of adult monkeys prenatally exposed to cocaine. In the first study, drug-exposed monkeys exhibited less flexibility than controls in adjusting to changing circumstances; in the second study, drug-exposed males exhibited a greater preference than controls for having rewards right away, a sign of impulsivity.

Director's Perspective

Research Focuses on Groups With High Smoking Rates

Dr. Volkow discusses NIDA’s efforts to develop effective antismoking treatments for populations with persistently high rates of smoking, such as people with psychiatric disorders, high school dropouts, and Native Americans.
Director's Perspective

Substance Abuse Among Older Adults

Understanding and responding to drug abuse among America’s aging population becomes more urgent as a growing percentage of baby boomers enter the over-50 age bracket.

Basic Science

Marker for Neuronal Damage Resolves a Year after Methamphetamine

New results extend previous findings that some methamphetamine-induced neuronal damage resolves after a year of abstinence.

Treatment

Prison Use of Medications for Opioid Addiction Remains Low

Describes results from a nationwide survey among correctional facilities on the use of opioid replacement therapy for people who are addicted to heroin.

Prevention

Drugs Contribute to High Rates of Sexually Transmitted Diseases Among Juvenile Offenders

Describe a study of newly arrested youths where researchers found correlations between the youths' prevalence of these sexually transmitted diseases and their cocaine and marijuana use.

Treatment

Methamphetamine Abuse Undermines Dental Health

Describes research that sheds light on the correlation between increased dental disease and methamphetamine abuse.
Epidemiology

Marijuana Linked With Testicular Cancer

Reports on a study of close to 400 Washington State men that found that those who use marijuana may increase their risk for developing testicular cancer.
Basic Science

Crack Cocaine Promotes Progression of HIV Infection to AIDS

Reports on two studies showing a high prevalence of HIV infection and more rapid progression to disability and death among drug abusers.
Bulletin Board

Reality Videos Bring NIDA Scientists to Web Site for Teens

Highlights new video clips on NIDA's Web site for teens that explore the dangers of drug abuse and that address questions from youth and their parents on the topic.
Epidemiology

Injection Drug Users Acquire Hepatitis C Infection Later in Developed Countries

Reports trends in onset of injection drug use to infection with hepatitis C virus in developed countries and notes the influence of prevention efforts.
Basic Science

Extended Cocaine Exposure Impairs Cognitive Function in Rats

Reports an animal study presenting evidence that cocaine causes cognitive deficits that can persist well into abstinence.

Bulletin Board

Annual Event Teaches Students Brain Science

Highlights activities held during Brain Awareness Week for students in Maryland, Virginia, and Washington, DC, to learn about brain anatomy and function.

Bulletin Board

NIDA Initiates Pediatrics Symposium on Adolescent Health

Presents highlights of a symposium sponsored by NIDA in October 2008 to discuss adolescent brain and cognitive development and consider the impact of drug abuse on young people.

Basic Science

Prenatal Nicotine Exposure May Damage Receptors That Influence Auditory Processing

Reports on a series of animal experiments indicating that nicotine exposure during prenatal fetal development damages a set of receptors in the brain's auditory processing center.

Prevention

Behavioral Problems Related to Maternal Smoking During Pregnancy Manifest Early in Childhood

Describes research providing evidence that maternal smoking during pregnancy contributes to behavioral conduct disorders among toddlers, school-age children, and teens.

Basic Science

Morphine-Induced Immunosuppression, From Brain to Spleen

Reports on scientists who pinpointed the biochemical trigger from morphine that sets off a chain reaction that inhibits an immune cell that is key in fighting viruses and cancer.

Epidemiology

Reduced Longevity Among Male Heroin Abusers, 1962-1997

Reviews the changing lifespan of heroin abusers as compared with that of the general U.S. population based on 1962-1997 data.

Basic Science

Animal Studies Elaborate Toluene's Effects

Reports on evidence that toluene abuse can harm the nervous system and body, although scientists know relatively little about its specific actions.

Basic Science

Methamphetamine Restricts Fetal Growth, Increases Lethargy in Newborns

Reports on research showing that newborns whose mothers abused methamphetamine during pregnancy showed lower rates of fetal growth as compared with unexposed newborns.

Long-Term Cocaine Abuse Linked With Impaired Heart Function

Summarizes research on the effects of long-term regular cocaine abuse on the cardiovascular system in African Americans.

Study Links Anabolic Steroids to Brain Changes in Adolescent Female Mice

Reports on an animal study finding that links anabolic steroids to brain changes in adolescent female mice, changes that can potentially lead to steroid abuse.
Director's Perspective

Steroid Abuse Is a High-Risk Route to the Finish Line

Highlights research on the effects of steroid use on the brain and the rest of the body, and stresses the need to educate young people about the serious health risks associated with its use.

Marijuana Smoking Is Associated With a Spectrum Of Respiratory Disorders

Highlights two studies suggesting significant associations between marijuana smoking and respiratory disease.
Basic Science

Stress Response May Underlie African- Americans' Reduced Pain Tolerance

Summarizes research suggesting a physiological difference as the explanation for African-Americans' reported low tolerance for pain.

NIDA Notes

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