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NIDA Notes

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NIDA Notes keeps you up to date on research advances in the causes, consequences, prevention, and treatment of drug abuse and addiction and HIV/AIDS.

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Study Points to Individualized Therapy for Opioid Addiction (February 2015)

Trial participants who were addicted to opioid painkillers and did not inject drugs stayed in treatment longer and achieved better outcomes than those who were addicted to heroin or injected drugs.

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Patients Addicted to Opioid Painkillers Achieve Good Results With Outpatient Detoxification (February 2015)

A significant portion of individuals who are addicted to opioid painkillers may initiate and maintain abstinence with a brief but intensive outpatient detoxification treatment followed by opioid antagonist therapy using naltrexone.

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Animal Study Suggests Marijuana May Affect Future Offspring’s Susceptibility to Heroin (February 2015)

Can marijuana use put offspring at heightened risk for opiate addiction, even if the use stops before the offspring are conceived? Results from a recent NIDA-funded study are consistent with other studies suggesting that a parent’s history of drug use, even preconception, may affect a child’s brain function and behavior.

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Waletzky Memorial Award Winners’ Lectures at NIDA Illuminate Cocaine’s Many Effects on Brain Structure, Circuitry (January 2015)

Dr. Paul E. M. Phillips spoke on “Phasic Dopamine Transmission During Substance Abuse,” describing investigations that he has led into the role of brief, seconds-long bursts of dopamine signaling in addictive processes. Dr. Rita Z. Goldstein spoke on “Targeting the Brain, Cognition, and Motivation for Intervention in Addiction.”

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Narrative of Discovery: In Search of a Medication To Treat Methamphetamine Addiction (January 2015)

This is the first in a series of NIDA Notes articles that will follow a team of researchers seeking a medication for methamphetamine addiction. This installment describes the early promise of the compound lobeline and the new directions the team discovered in studying it.

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Communities That Care System Helps Prevent Problem Behaviors in Youth Through 12th Grade (December 2014)

Extending the prevention interventions to target risk factors through the high school years could strengthen effects on substance use and delinquent behaviors on the cusp of adulthood.

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Varenicline Helps People With Mental Illness Maintain Abstinence From Smoking (November 2014)

The finding from an 18-month-long clinical trial strengthens hope that pharmacotherapy can break nicotine’s especially tenacious hold on people with serious mental illness such as bipolar disorder or schizophrenia.

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Study Assesses Functional Deficits Due to HIV and Methamphetamine Use (November 2014)

Methamphetamine use and HIV infection raise the risk for functional dependence, or the need for assistance with everyday tasks. People who use methamphetamine and are HIV positive showed the highest levels of functional dependence in most domains of daily life.

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NIDA To Provide Travel Awards to Junior Investigators Conducting Research Focused on Women and Sex/Gender Differences in Drug Abuse (November 2014)

NIDA plans to provide $750 travel awards to 27 junior investigators to present their research on women or sex/gender differences in any area of drug abuse at the annual meeting of the College on Problems of Drug Dependence in Phoenix, Arizona, June 13–18, 2015. Deadline to apply is December 5, 2014.

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Animation: The Rise and Fall of the Cocaine High (November 2014)

This animation shows the rapid passage of cocaine through the brain. It demonstrates that the intensity of the cocaine “high” parallels the trajectory of cocaine levels in the brain.

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