Do specific nutrients influence neuronal function?
What specific brain areas are affected by specific nutrients, how are they affected, and what are the molecular mechanisms underlying pathological or physiological changes that occur in those areas as a result of different nutrition states?
Can nutrient deficiencies be reversed by replacement therapy?
How do genetics influence the interactions between nutrients and metabolic and behavioral processes?
~ 40 micronutrients, and their coenzymes and metals that are needed for proteins. The brain needs micronutrients.
With micronutrient deficiency proteins needed for survival have tightened bonding and proteins that are more long-term (i.e., prevent aging), "lose."
Choline important during pregnancy:
Brain (hippocampal) development
Later memory function-
Lower histone methylation
Reversing some aspects of FAS
Iron deficiency during development affects the DA system
TH is iron dependent enzyme to get l-dopa
Zinc deficiency associated with higher glucocorticoids
Omega 3 associated with improved mood, cognitive development, neuro-plasticity, synaptogenesis
DHA associated with neuroprotectin D1 (NPD1) molecule
Potential Areas of Research for NIDA:
Effects of dietary deficiencies on neuroplasticity; substance abuse
Balance and interaction among multiple nutrients, as opposed to study of individual nutrients
The need for investigating multiple targets in order to influence prevention and treatment of chronic disease states
Nutritional effects on the post-developing brain; developing methods to study
Gender/sex differences relative to the effects from nutrition and diet; effects of sex hormones on nutrient metabolism
The effects of nutrition/nutrients on relapse in a rehabilitation model, in addition to prevention and maintenance of addiction
Relationship between nutrition and neuroAIDs in drug abuse with respect to early cell death and early cognitive decline