This illustration provides diagrams of neurotransmitter release at synapses in the presence or absence of benzodiazapines. The first diagram shows that in the absence of benzodiazapines, GABA released from an axon of a neuron earlier in the pathway binds to an alpha-1 GABAA receptor on an inhibitory interneuron. Synapses on the axon of that interneuron then release GABA that binds to an alpha-3 GABAA receptor at a synapse of a dopamine neuron. The binding reduces that neuron’s dopamine release at its axonal synapse. The second illustration shows that benzodiazapines currently on the market bind to the alpha-1 GABAA receptor on an inhibitory interneuron, reducing GABA binding there and subsequent GABA release by that neuron. Without the normal GABA influence, the dopamine neuron releases more dopamine than in the first diagram.