It is with sadness that we mourn the death of Dr. Charles R. Schuster, a much admired and respected member of our scientific community and past NIDA director. Dr. Schuster, who died February 21, 2010, was a pioneer in substance abuse and addiction, opening the path to new research approaches that today are promising treatment strategies. He has authored or co-authored more than 200 scientific journal articles, as well as numerous book chapters and several books. Prior to his death, Dr. Schuster was director of the Addiction Research Institute at Wayne State University. For those wishing to make contributions in his honor, the Schuster family encourages donations to the Friends of NIDA, a nonprofit coalition dedicated to the elimination of drug abuse and addiction.