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NIDA Notes Articles: Genetics

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PhenX Toolkit Provides Standard Measures for Research

julio del 2012
NIDA researchers working with human subjects now have a new resource at their fingertips: the PhenX Toolkit’s new Substance Abuse and Addiction (SAA) Collection. The Toolkit is designed to provide standardized measures, vetted and approved by the field, to help researchers compare and combine data from multiple studies.

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Resting Brain Studies Shed New Light on Vulnerabilities

noviembre del 2011

Individuals with weak signaling in a nicotine-sensitive brain circuit were more vulnerable to nicotine dependence than those with stronger signaling, according to a study conducted while the subjects’ brains were in a resting state. A second resting-state study finds that the same circuit appears to mediate dependence associated with a genetic risk factor for smoking.

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Smokers Who Quit May Have Genetic Advantage

noviembre del 2009

Describes research providing evidence that genes may influence how successful a person is in quitting smoking and which cessation technique may work best for them.

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Stress Receptor Mediates Lifelong Consequences of Early Trauma

noviembre del 2012

NIDA-supported research suggests that glucocorticoid receptor levels during early brain development affect the hard wiring of neural circuits that shape an individual’s basic emotional makeup. In mice, overexpression of the glucocorticoid gene in the first weeks after birth increased anxiety and response to cocaine in adulthood. These findings may help researchers understand the genetic background and the developmental trajectory of addiction.

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Studies Link Family of Genes to Nicotine Addiction

diciembre del 2009

Reports study results suggesting that genes for several acetylcholine receptor proteins influence early smoking responses and the likelihood of nicotine dependence.

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Study Finds Genetic Influence on African Americans’ Smoking

noviembre del 2013

A meta-analysis of 13 genome-wide association studies of African Americans’ smoking patterns confirms the significance of genetic variation in region 15q25.1. The analysis also tentatively implicates several genome locations that have not previously been associated with smoking behaviors.

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Three Scientists Join Advisory Council

diciembre del 2010
Announces three new NIDA National Advisory Council on Drug Abuse members and describes their drug abuse and addiction research experience.

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Workgroup Directs Search for Genes That Influence Addiction

abril del 2010

Highlights NIDA’s research portfolio to identify the genes and genetic processes responsible for a person’s vulnerability to drug abuse.

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