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NIDA Notes Articles: Ciencia de la adicción

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Lower Levels of Dopamine-Regulating Receptors Among Novelty Seekers

octubre del 2010

Describes research results reporting that people who favor novelty have lower-than-average availability of a receptor that inhibits dopamine's release from neurons, which likely stimulates the activity of reward circuits.

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Methamphetamine Abuse Alters Response to Facial Cues

octubre del 2009

Highlights research showing methamphetamine abusers may have more difficulty than nonabusers in responding with empathy and self-control to people who are experiencing intense emotions.

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Methamphetamine Abusers Show Increased Distractibility

abril del 2009

Highlights findings from a study of former methamphetamine abusers showing evidence of impairment in areas of the brain known to influence cognition, emotion, and decision making.

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Methamphetamine Alters Brain Structures, Impairs Mental Flexibility

Marzo del 2014

Methamphetamine alters brain structures involved in decision-making and impairs the ability to suppress habitual behaviors that have become useless or counterproductive. The two effects were correlated, indicating that the structural change underlies the decline in mental flexibility.

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Methamphetamine Turns Helper Cells Into Destroyers

noviembre del 2009

Describes research providing evidence that chronic methamphetamine abuse is associated with increased microglial cell activity in the brain leading to neurodegeneration.

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Mice With Genetic Alteration Eschew Cocaine

junio del 2008

Reports on a study involving researchers who successfully desensitized mice to cocaine by genetically altering their dopamine transporters.

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Molecular Alterations of DNA Contribute to Persistence of Memory

noviembre del 2011
In a new series of studies tracing the molecular events that occur in the brain as memories are formed and preserved, researchers find that certain epigenetic changes may promote vulnerability to relapse.

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N-Acetylcysteine Postsynaptic Effect Limits Efficacy

enero del 2013

Clinical trials of N-acetylcysteine to help people recovering from drug abuse avoid relapse have demonstrated only moderate efficacy. New NIDA-supported research shows that while a low dose of the medication activates receptors associated with lowered drug-seeking behavior, a higher dose appears to activate receptors associated with increased drug-seeking behavior. The result suggests that a medication or combination of medications that stimulate the receptor GluR2/3 and block mGluR5 may work better than N-acetylcysteine alone.

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Neuropeptide Promotes Drug-Seeking and Craving in Rats

octubre del 2007
Reports on two studies indicating that orexin, a neuropeptide that stimulates eating and regulates wakefulness, also fosters animals' drug seeking and craving responses to drugs.

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Neuroscience Blueprint Promotes Efficiency, Synergy

junio del 2008

Describes a knowledge- and resource-sharing system for NIH-funded neuroscientists to access to data, advanced research tools, and technical assistance.

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Toma el reto nacional sobre el coeficiente intelectual (CI) sobre las drogas