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NIDA Notes Articles: Basic Science

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Methamphetamine Restricts Fetal Growth, Increases Lethargy in Newborns

junio del 2008

Reports on research showing that newborns whose mothers abused methamphetamine during pregnancy showed lower rates of fetal growth as compared with unexposed newborns.

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Animal Studies Elaborate Toluene's Effects

junio del 2008

Reports on evidence that toluene abuse can harm the nervous system and body, although scientists know relatively little about its specific actions.

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Mice With Genetic Alteration Eschew Cocaine

junio del 2008

Reports on a study involving researchers who successfully desensitized mice to cocaine by genetically altering their dopamine transporters.

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Morphine-Induced Immunosuppression, From Brain to Spleen

junio del 2008

Reports on scientists who pinpointed the biochemical trigger from morphine that sets off a chain reaction that inhibits an immune cell that is key in fighting viruses and cancer.

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Chromosome 17 Harbors Opioid Dependence Genes

Marzo del 2008

Describes the work of researchers who have found a statistical link between one region on chromosome 17 and an increased risk of opioid dependence.

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Not All Mesolimbic Dopamine Neurons Are Alike

Marzo del 2008

Reports on research showing that the neurons that deliver dopamine to two regions of the brain's mesolimbic reward system respond differently to opioids, an important finding for drug treatment research.

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Cocaine Can Mobilize Stored Dopamine

Marzo del 2008

Describes a study showing that cocaine, which increases dopamine levels, also can tap into an intracellular dopamine reserve pool.

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Gene Experiment Confirms a Suspected Cocaine Action

octubre del 2007

Reports on the work of addiction researchers who are learning how acute and chronic cocaine exposure regulates certain genes, based on knowledge from developmental and cancer biology.

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Impacts of Drugs on Neurotransmission

octubre del 2007

Discusses the central importance of studying drugs' effects on neurotransmission and describes some of the most common experimental methods used in this research.

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Exposure to Morphine During Early Adolescence Sensitizes Rats as Adults

octubre del 2007

Presents highlights of a study indicating that exposure to morphine during adolescence may increase sensitivity to the drug during adulthood.

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