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NIDA Notes Articles: Basic Science

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Sensory Aspects of Smoking May Counter Bad Mood, Craving

octubre del 2009

Describes study findings revealing that the act of smoking, apart from actual or expected nicotine delivery, may soothe a smoker's negative mood.

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Manic Mice Show Heightened Sensitivity to Rewards

octubre del 2009

Reports on an animal study suggesting that the manic stage of bipolar disorder promotes signs of drug abuse vulnerability by enhancing sensitivity to rewards, both natural and drug-related.

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Adolescent Rats Self-Administer More Nicotine Than Adults

abril del 2009

Highlights an animal study involving the self-administration of nicotine among adolescent and adult rats to gain understanding of their potential vulnerability to the substance.

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Methamphetamine Abusers Show Increased Distractibility

abril del 2009

Highlights findings from a study of former methamphetamine abusers showing evidence of impairment in areas of the brain known to influence cognition, emotion, and decision making.

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Cocaine Locks Rats Into Unrewarding Behaviors

abril del 2009

Describes research with rats to better understand cocaine’s effect on the neural signaling in the learning circuits of the brain.

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Prenatal Nicotine Exposure May Damage Receptors That Influence Auditory Processing

abril del 2009

Reports on a series of animal experiments indicating that nicotine exposure during prenatal fetal development damages a set of receptors in the brain's auditory processing center.

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Damage to Brain Area May Immediately Halt Cigarette Addiction

abril del 2009

Describes a study among people who had sustained brain injuries to investigate whether certain damaged areas of the brain are associated with the ability to quit smoking.

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New Tracer for Nicotinic Receptors Promises Improved Specificity

abril del 2009

Reports on NIDA researchers who developed a new tracer compound that binds readily to nicotine receptors and enhances positron emission tomography images.

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Low Dopamine Receptor Availability May Promote Cocaine Addiction

abril del 2009

Describes findings from an animal study showing that cocaine lowers availability of dopamine receptors in the basal ganglia, an area of the brain that includes portions of the reward system.

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Imaging Studies Elucidate Neurobiology of Cigarette Craving

diciembre del 2008

Reports on three separate imaging studies illuminating the neurobiology of cigarette craving.

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