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NIDA Notes Articles: Basic Science

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Rare Glutamate Receptor Proliferates After Cocaine Withdrawal

diciembre del 2009

Reports findings that a rare neuroreceptor may be linked to the intensive cravings cocaine abusers experience during their first weeks of abstinence.

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Rats Reared Alone Show ADHD Signs

diciembre del 2009

Describes an animal study showing that rats raised in isolation may prove useful in future studies exploring the neurobiology that links impulsivity and vulnerability to addiction.

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Receptor Complexes Link Dopamine to Long-Term Neuronal Effects

octubre del 2009

Reports on a discovery of previously unrecognized dopamine receptors in the brain that when triggered by drug abuse lead to potentially long-term neuronal effects.

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Resting Brain Studies Shed New Light on Vulnerabilities

noviembre del 2011

Individuals with weak signaling in a nicotine-sensitive brain circuit were more vulnerable to nicotine dependence than those with stronger signaling, according to a study conducted while the subjects’ brains were in a resting state. A second resting-state study finds that the same circuit appears to mediate dependence associated with a genetic risk factor for smoking.

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Sensory Aspects of Smoking May Counter Bad Mood, Craving

octubre del 2009

Describes study findings revealing that the act of smoking, apart from actual or expected nicotine delivery, may soothe a smoker's negative mood.

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Stimulants in “Bath Salts” Produce Effects Similar to MDMA

agosto del 2013

Mephedrone and methylone, two stimulants commonly found in designer drugs such as “bath salts,” act on the brain much like MDMA (Ecstasy).

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Stress Receptor Mediates Lifelong Consequences of Early Trauma

noviembre del 2012

NIDA-supported research suggests that glucocorticoid receptor levels during early brain development affect the hard wiring of neural circuits that shape an individual’s basic emotional makeup. In mice, overexpression of the glucocorticoid gene in the first weeks after birth increased anxiety and response to cocaine in adulthood. These findings may help researchers understand the genetic background and the developmental trajectory of addiction.

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Stress Response May Underlie African- Americans' Reduced Pain Tolerance

octubre del 2006

Summarizes research suggesting a physiological difference as the explanation for African-Americans' reported low tolerance for pain.

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Stress-Induced Enzyme Compounds Methamphetamine Neurotoxicity

enero del 2014

Ketoprofen, an anti-inflammatory agent commonly prescribed to treat arthritis, reduces neuronal damage in rats that have been exposed to chronic stress and methamphetamine. If this finding of a recent NIDA-supported study extrapolates to humans, anti-inflammatory medications may gain a place in the treatment of methamphetamine addiction.

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Studies Link Family of Genes to Nicotine Addiction

diciembre del 2009

Reports study results suggesting that genes for several acetylcholine receptor proteins influence early smoking responses and the likelihood of nicotine dependence.

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