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NIDA Notes Articles: Basic Science

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Mice With Genetic Alteration Eschew Cocaine

junio del 2008

Reports on a study involving researchers who successfully desensitized mice to cocaine by genetically altering their dopamine transporters.

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Molecular Alterations of DNA Contribute to Persistence of Memory

noviembre del 2011
In a new series of studies tracing the molecular events that occur in the brain as memories are formed and preserved, researchers find that certain epigenetic changes may promote vulnerability to relapse.

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Morphine-Induced Immunosuppression, From Brain to Spleen

junio del 2008

Reports on scientists who pinpointed the biochemical trigger from morphine that sets off a chain reaction that inhibits an immune cell that is key in fighting viruses and cancer.

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Neuropeptide Promotes Behaviors Tied to Addiction and Overeating

julio del 2011

Reports on several studies implicating a certain neuropeptide (a signaling molecule) in fostering addition and overeating and discusses implications for addiction treatment.

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New Class of Regulators for Addiction Genes

noviembre del 2011
New studies show that microRNAs, snippets of RNA implicated in a wide variety of biological processes, are involved in promoting and inhibiting cocaine addiction. The findings could pave a new path for the development of anti-addiction therapies.

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New Insight Into How Cues Cause Relapse to Cocaine

mayo del 2014

A brain response occurs in the nucleus accumbens when rats encounter a cue that they associate with previous cocaine self-administration, but not a cue associated with a pleasurable non-drug experience. Moreover, the response correlates in time and intensity with the animals’ cue-induced relapse to cocaine-seeking.

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New Method Uncovers How Internal States Influence the Living Brain to Change Behavior

Marzo del 2012
In an innovative NIDA-funded study, published in Cell, scientists introduced a modified dopamine receptor gene into the brain of a living vinegar fly

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New Technique Links 89 Genes to Drug Dependence

septiembre del 2008

Presents research findings linking 89 genes to drug abuse and dependence, found using genome-wide association studies, a new technique for identifying genes.

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New Tracer for Nicotinic Receptors Promises Improved Specificity

abril del 2009

Reports on NIDA researchers who developed a new tracer compound that binds readily to nicotine receptors and enhances positron emission tomography images.

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Nicotine Boosts Mood, Brain Dopamine Levels

noviembre del 2009

Highlights findings from a study showing that nicotine triggers a surge in levels of the neurotransmitter dopamine in the brain's main reward area for cigarette smokers.

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