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NIDA Notes Articles: Basic Science

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Gene Experiment Confirms a Suspected Cocaine Action

octubre del 2007

Reports on the work of addiction researchers who are learning how acute and chronic cocaine exposure regulates certain genes, based on knowledge from developmental and cancer biology.

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Gene Influences Impact of Maternal Smoking on Children's Behavioral Problems

julio del 2011
Describes research showing that the combination of prenatal smoking exposure and specific genes increases children’s and adolescent’s risk for behavior problems.

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Gene Variants Reduce Opioid Risks

junio del 2014

Two recent studies suggest that genotyping may enable clinicians to base therapies on individual patients’ potential responsiveness to opioid drugs’ therapeutic effects and vulnerability to their harmful effects.

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Genetic Overlap Between Substance Abuse and Bipolar Disorder

abril del 2010

Describes a literature analysis reporting on the prevalence of people with bipolar disorder who also have a substance use disorder and discusses the genetic link that may contribute to this comorbidity.

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Imaging Studies Elucidate Neurobiology of Cigarette Craving

diciembre del 2008

Reports on three separate imaging studies illuminating the neurobiology of cigarette craving.

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Immune System Plays Unexpected Role in Brain Development

septiembre del 2008

Describes research findings demonstrating that the immune system participates in the shaping of brain circuits during a child's development, a finding that may shed light on the origins of neurodegenerative diseases.

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Impacts of Drugs on Neurotransmission

octubre del 2007

Discusses the central importance of studying drugs' effects on neurotransmission and describes some of the most common experimental methods used in this research.

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In Animals, Receptor Puts Brakes on Nicotine Consumption

Marzo del 2012

New research suggests that differences in tobacco consumption reflect, in part, differences in the functional efficacy of a specific type of receptor in a pathway of the brain. In animal studies, nicotinic acetylcholine receptors with the α5 subunit played a key role in producing aversive responses to nicotine, thereby dissuading further consumption of the drug.

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Investigators Map Functional Networks in the Rat Brain

junio del 2012
Researchers have mapped the fundamental functional organization of the rat brain and shown that it resembles that of the human brain.

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Long-Term Cocaine Self-Administration Depresses Brain Activity

diciembre del 2008

Discusses research exploring how widespread the reduction of neural activity is in the brain with chronic exposure to cocaine.

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