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NIDA Notes Articles: Basic Science

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Crack Cocaine Promotes Progression of HIV Infection to AIDS

octubre del 2010
Reports on two studies showing a high prevalence of HIV infection and more rapid progression to disability and death among drug abusers.

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Damage to Brain Area May Immediately Halt Cigarette Addiction

abril del 2009

Describes a study among people who had sustained brain injuries to investigate whether certain damaged areas of the brain are associated with the ability to quit smoking.

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Device Detects Marijuana in Breath Hours After Smoking

mayo del 2014

Driving under the influence of marijuana is a dangerous public health concern. NIDA researchers have discovered that breath expelled into a Breathalyzer-style collection device contained measurable amounts of THC for up to 2 hours after participants in a recent clinical trial smoked the drug.

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Disruption of Neuron Production in Adult Rats Increases Cocaine Taking

noviembre del 2011
Drug abuse may diminish production of new neurons in the brain’s hippocampus and thereby increase vulnerability to drug addiction.

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Dr. Antonello Bonci Q & A: Lighting Up the Brain To Shut Down Cocaine Seeking

julio del 2014

The Scientific Director of NIDA’s Intramural Research Program talks about switching off animals’ compulsive cocaine seeking by optogenetically activating the prefrontal cortex, and the implications of this work for people. In an accompanying podcast, Dr. Bonci walks viewers through experiments that showed that prefrontal cortex activity levels may constitute a simple switch controlling whether or not animals compulsively seek cocaine.

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Drug Cues Outside Awareness Rapidly Trigger Brain's Emotion Centers

octubre del 2009

Describes research showing that cocaine abusers appear to have a rapid neural response to reward cues outside of their awareness, possibly signifying vulnerability to relapse.

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Ethnic Groups Have Contrasting Genetic Risks for Nicotine Addiction

octubre del 2009

Describes research exploring differences and similarities in the genetic profiles of African-Americans and European-Americans who are heavy smokers.

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Exposure to Morphine During Early Adolescence Sensitizes Rats as Adults

octubre del 2007

Presents highlights of a study indicating that exposure to morphine during adolescence may increase sensitivity to the drug during adulthood.

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Extended Cocaine Exposure Impairs Cognitive Function in Rats

noviembre del 2009

Reports an animal study presenting evidence that cocaine causes cognitive deficits that can persist well into abstinence.

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Gene Experiment Confirms a Suspected Cocaine Action

octubre del 2007

Reports on the work of addiction researchers who are learning how acute and chronic cocaine exposure regulates certain genes, based on knowledge from developmental and cancer biology.

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Toma el reto nacional sobre el coeficiente intelectual (CI) sobre las drogas