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NIDA Notes Articles: Basic Science

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A Genetic Nexus of Obesity and Smoking

octubre del 2014

Research shows that some gene variants that influence body mass index also shape smoking behaviors.

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Adolescent Rats Self-Administer More Nicotine Than Adults

abril del 2009

Highlights an animal study involving the self-administration of nicotine among adolescent and adult rats to gain understanding of their potential vulnerability to the substance.

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Animal Studies Elaborate Toluene's Effects

junio del 2008

Reports on evidence that toluene abuse can harm the nervous system and body, although scientists know relatively little about its specific actions.

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Animation: The Rise and Fall of the Cocaine High

noviembre del 2014

This animation shows the rapid passage of cocaine through the brain. It demonstrates that the intensity of the cocaine “high” parallels the trajectory of cocaine levels in the brain.

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Brain Adaptation May Dampen Effects of Cocaine

octubre del 2010
Reports evidence that a cocaine-induced change in the structure of brain cells represents an adaptive response that may limit the drug’s impact.

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Brain Opioid Receptor Levels Predict Time to Cocaine Relapse

octubre del 2010
Describes study findings revealing that cocaine abusers who maintain high levels of a certain receptor in their brain during early abstinence relapse sooner than abusers whose levels drop.

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Brain Proteins Differ in Cocaine-Overdose Victims

diciembre del 2008

Describes research findings showing differences in protein concentrations in the brain pleasure centers of people who died from cocaine overdose as compared with those who did not abuse the drug.

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Chromosome 17 Harbors Opioid Dependence Genes

Marzo del 2008

Describes the work of researchers who have found a statistical link between one region on chromosome 17 and an increased risk of opioid dependence.

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Cocaine Alters Production of Hundreds of Proteins

Marzo del 2011

Describes research findings that show that chronic cocaine abuse may change the production of many proteins in the neurons of the brain’s reward system, aiding in our understanding how the drug causes addiction.

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Cocaine Can Mobilize Stored Dopamine

Marzo del 2008

Describes a study showing that cocaine, which increases dopamine levels, also can tap into an intracellular dopamine reserve pool.

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