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NIDA Notes Articles: Basic Science

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Extended Cocaine Exposure Impairs Cognitive Function in Rats

noviembre del 2009

Reports an animal study presenting evidence that cocaine causes cognitive deficits that can persist well into abstinence.

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Nicotine Boosts Mood, Brain Dopamine Levels

noviembre del 2009

Highlights findings from a study showing that nicotine triggers a surge in levels of the neurotransmitter dopamine in the brain's main reward area for cigarette smokers.

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Methamphetamine Turns Helper Cells Into Destroyers

noviembre del 2009

Describes research providing evidence that chronic methamphetamine abuse is associated with increased microglial cell activity in the brain leading to neurodegeneration.

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Rats Reared Alone Show ADHD Signs

diciembre del 2009

Describes an animal study showing that rats raised in isolation may prove useful in future studies exploring the neurobiology that links impulsivity and vulnerability to addiction.

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Rare Glutamate Receptor Proliferates After Cocaine Withdrawal

diciembre del 2009

Reports findings that a rare neuroreceptor may be linked to the intensive cravings cocaine abusers experience during their first weeks of abstinence.

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Studies Link Family of Genes to Nicotine Addiction

diciembre del 2009

Reports study results suggesting that genes for several acetylcholine receptor proteins influence early smoking responses and the likelihood of nicotine dependence.

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Peer Interaction Enhances Adolescent Rats' Drug Reward

abril del 2010
Describes an animal study reporting that peer interaction enhances adolescent rats’ drug reward and discusses the impact of these findings to future research on drug reward in social context.

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Genetic Overlap Between Substance Abuse and Bipolar Disorder

abril del 2010

Describes a literature analysis reporting on the prevalence of people with bipolar disorder who also have a substance use disorder and discusses the genetic link that may contribute to this comorbidity.

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Brain Opioid Receptor Levels Predict Time to Cocaine Relapse

octubre del 2010
Describes study findings revealing that cocaine abusers who maintain high levels of a certain receptor in their brain during early abstinence relapse sooner than abusers whose levels drop.

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Lower Levels of Dopamine-Regulating Receptors Among Novelty Seekers

octubre del 2010

Describes research results reporting that people who favor novelty have lower-than-average availability of a receptor that inhibits dopamine's release from neurons, which likely stimulates the activity of reward circuits.

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