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NIDA Notes Articles: Basic Science

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Morphine-Induced Immunosuppression, From Brain to Spleen

junio del 2008

Reports on scientists who pinpointed the biochemical trigger from morphine that sets off a chain reaction that inhibits an immune cell that is key in fighting viruses and cancer.

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Immune System Plays Unexpected Role in Brain Development

septiembre del 2008

Describes research findings demonstrating that the immune system participates in the shaping of brain circuits during a child's development, a finding that may shed light on the origins of neurodegenerative diseases.

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Optical Technologies Expand Vistas Into the Brain

septiembre del 2008

Describes new tools under development, including one to visualize cells deep in the brain and another one that remotely activates brain cells.

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New Technique Links 89 Genes to Drug Dependence

septiembre del 2008

Presents research findings linking 89 genes to drug abuse and dependence, found using genome-wide association studies, a new technique for identifying genes.

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Brain Proteins Differ in Cocaine-Overdose Victims

diciembre del 2008

Describes research findings showing differences in protein concentrations in the brain pleasure centers of people who died from cocaine overdose as compared with those who did not abuse the drug.

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Imaging Studies Elucidate Neurobiology of Cigarette Craving

diciembre del 2008

Reports on three separate imaging studies illuminating the neurobiology of cigarette craving.

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Long-Term Cocaine Self-Administration Depresses Brain Activity

diciembre del 2008

Discusses research exploring how widespread the reduction of neural activity is in the brain with chronic exposure to cocaine.

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New Tracer for Nicotinic Receptors Promises Improved Specificity

abril del 2009

Reports on NIDA researchers who developed a new tracer compound that binds readily to nicotine receptors and enhances positron emission tomography images.

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Low Dopamine Receptor Availability May Promote Cocaine Addiction

abril del 2009

Describes findings from an animal study showing that cocaine lowers availability of dopamine receptors in the basal ganglia, an area of the brain that includes portions of the reward system.

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Adolescent Rats Self-Administer More Nicotine Than Adults

abril del 2009

Highlights an animal study involving the self-administration of nicotine among adolescent and adult rats to gain understanding of their potential vulnerability to the substance.

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