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NIDA Notes Articles: Treatment

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Medications That Normalize Brain Glutamate Reduce Drug-Seeking in Rats

octubre del 2010

Reports on two studies that demonstrate the promise of treating addiction with medications that alleviate drug-induced alterations in signaling by the neurotransmitter glutamate.

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Medications That Treat Opioid Addiction Do Not Impair Liver Health

diciembre del 2013

A trial of buprenorphine/naloxone (Bup/Nx) showed no evidence that the medicine was associated with liver damage. The drug gave results similar to those of methadone. The study data indicate that although most patients can be treated safely with either methadone or Bup/Nx without major concern for liver injury, clinicians are advised to continue to monitor the liver health of their patients who are on methadone or Bup/Nx therapy.

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Methadone Reduces Rats' Cocaine Seeking

diciembre del 2008

Reports on an animal study showing that methadone, normally used as a therapy for opioid abuse, may prove to be an effective treatment for cocaine abuse.

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Methadone Therapy in Prison Benefits Men a Year Out

noviembre del 2009

Describes clinical trial results providing evidence that methadone maintenance to men in prison can pay off in better retention in community treatment and reduced drug abuse following their release.

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Methamphetamine Abuse Undermines Dental Health

julio del 2011

Describes research that sheds light on the correlation between increased dental disease and methamphetamine abuse.

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Microneedle Milestone: One Week of Transdermal Drug Delivery

Marzo del 2014

Microneedles are an innovative technique for delivering medications through the skin, a route that could particularly benefit patients receiving naltrexone therapy for opioid and alcohol dependence. Researchers have found a way to use the transdermal technique to deliver a single treatment of naltrexone that lasts for 7 days.

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Modafinil Normalizes Sleep During Early Cocaine Abstinence

diciembre del 2010

Describes a study investigating the effectiveness of modafinil in enhancing sleep among cocaine abusers who are currently abstinent.

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More Convenient Preparations of Buprenorphine Pass Test

julio del 2012

Soluble-film preparations of buprenorphine suppressed heroin abusers’ withdrawal symptoms with no serious side effects in a recent clinical trial. They dissolved more rapidly in the mouth than the pill form of the medication, providing faster relief.

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Morphine Speeds AIDS Onset in Monkeys

junio del 2008

Highlights the work of investigators who discovered key ways in which morphine may accelerate the progression of AIDS in animal studies.

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Multidimensional Family Therapy for Adolescent Drug Abuse Offers Broad, Lasting Benefits

diciembre del 2010

Describes findings from two randomized clinical trials showing that treatment with multidimensional family therapy resulted in fewer drug-related problems than treatment with cognitive behavior therapy.

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