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NIDA Notes Articles: Opioides

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Adolescent Cigarette, Alcohol Use Declines as Marijuana Use Rises

febrero del 2013

Fewer teens are using cigarettes, alcohol, and most illicit drugs, according to NIDA’s latest Monitoring the Future study. Troubling  trends persist in marijuana use, however, and nonmedical prescription drug use remains a concern.

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Animal Research Advances Effort to Develop Vaccines Against Cocaine, Heroin Abuse

septiembre del 2012

New vaccines that aim to promote recovery from cocaine and heroin abuse showed promise in animal testing. Both vaccines induced rats’ immune system to produce high titers of antibodies that inhibit the target drug from reaching the brain. The rats’ behaviors when given access to the target drug indicated that the vaccines reduced the reinforcing effects that, in recovering people, can cause lapses to turn into relapses.

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Few Teens With Prescription Opioid Use Disorders Receive Treatment

julio del 2012

Fewer than 12 percent of adolescents who meet diagnostic criteria for prescription opioid abuse or dependence receive any treatment, according to an analysis of data from the 2005 to 2008 National Survey on Drug Use and Health. The most common reason the adolescents gave for not receiving treatment was their lack of perceived need for it.

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More Convenient Preparations of Buprenorphine Pass Test

julio del 2012

Soluble-film preparations of buprenorphine suppressed heroin abusers’ withdrawal symptoms with no serious side effects in a recent clinical trial. They dissolved more rapidly in the mouth than the pill form of the medication, providing faster relief.

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Buprenorphine During Pregnancy Reduces Neonate Distress

julio del 2012

Sublingual buprenorphine is a safe and effective alternative to methadone for treating opioid dependence during pregnancy, finds the Maternal Opioid Treatment: Human Experimental Research (MOTHER) study, a NIDA-supported clinical trial. Women who received either medication had similar pregnancy and birth outcomes, but infants born to women who received buprenorphine had milder symptoms of neonatal opioid withdrawal.

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Prison Use of Medications for Opioid Addiction Remains Low

julio del 2011

Describes results from a nationwide survey among correctional facilities on the use of opioid replacement therapy for people who are addicted to heroin.

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Study Supports Methadone Maintenance in Therapeutic Communities

diciembre del 2010

Describes a study that examined the effectiveness of combining two therapies for drug abuse addiction: methadone treatment and therapeutic communities, two approaches that are rarely combined.

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Detoxification Services and Pharmacotherapies Lacking in Nation's Jails and Prisons

diciembre del 2010

Reports findings from a survey that revealed that although substance abuse is prevalent in jails and prisons, many correctional facilities do not offer detoxification services or therapies to aid in maintaining abstinence.

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Medications That Normalize Brain Glutamate Reduce Drug-Seeking in Rats

octubre del 2010
Reports on two studies that demonstrate the promise of treating addiction with medications that alleviate drug-induced alterations in signaling by the neurotransmitter glutamate.

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Young Opioid Abusers Benefit From Extended Buprenorphine-Naloxone Treatment

abril del 2010
Reports on a study investigating the benefits of extended opioid maintenance therapy that included drug counseling and 12 weeks of therapy with buprenorphine and naloxone.

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