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NIDA Notes Articles: Morphine

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Antipsychotic Drug Prevents Morphine Tolerance in Mice

abril del 2007
Summarizes animal studies indicating that an antipsychotic drug, trifluoperazine, prevents morphine tolerance in mice.

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Exposure to Morphine During Early Adolescence Sensitizes Rats as Adults

octubre del 2007

Presents highlights of a study indicating that exposure to morphine during adolescence may increase sensitivity to the drug during adulthood.

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Endorphin Derivative Inhibits Reward From Morphine and Nicotine in Rats

octubre del 2007

Describes research investigating a naturally occurring brain chemical that shows early promise as a treatment for addiction in animal studies.

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Neuropeptide Promotes Drug-Seeking and Craving in Rats

octubre del 2007
Reports on two studies indicating that orexin, a neuropeptide that stimulates eating and regulates wakefulness, also fosters animals' drug seeking and craving responses to drugs.

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Morphine-Induced Immunosuppression, From Brain to Spleen

junio del 2008

Reports on scientists who pinpointed the biochemical trigger from morphine that sets off a chain reaction that inhibits an immune cell that is key in fighting viruses and cancer.

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Morphine Speeds AIDS Onset in Monkeys

junio del 2008

Highlights the work of investigators who discovered key ways in which morphine may accelerate the progression of AIDS in animal studies.

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Program Helps Troubled Boys Reduce Substance Abuse

diciembre del 2011

Chronically delinquent boys in Multidimensional Treatment Foster Care reduced their substance abuse more than boys assigned to Community Group Care.

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Potential Pain Medication Targets Peripheral Nerves

septiembre del 2012

Researchers report a significant advance in the search for medications that can suppress pain but avoid opioids’ abuse potential and other undesirable CNS effects. A new compound reduces mouse responses in animal models of neurogenic and chronic inflammatory (e.g., arthritic) pain. The compound, called UB937, enhances the natural pain-killing activity of the neurotransmitter anandamide, and exerts its analgesic effects entirely in peripheral tissues, without entering the brain.

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