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NIDA Notes Articles: Cocaína

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Prenatal Cocaine Exposure Increases Monkeys' Impulsivity Into Adulthood

julio del 2012

Prenatal drug exposure can have behavioral effects that last well into adulthood, according to two studies of adult monkeys prenatally exposed to cocaine. In the first study, drug-exposed monkeys exhibited less flexibility than controls in adjusting to changing circumstances; in the second study, drug-exposed males exhibited a greater preference than controls for having rewards right away, a sign of impulsivity.

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Program Helps Troubled Boys Reduce Substance Abuse

diciembre del 2011

Chronically delinquent boys in Multidimensional Treatment Foster Care reduced their substance abuse more than boys assigned to Community Group Care.

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Rare Glutamate Receptor Proliferates After Cocaine Withdrawal

diciembre del 2009

Reports findings that a rare neuroreceptor may be linked to the intensive cravings cocaine abusers experience during their first weeks of abstinence.

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Recovery May Be Harder for Adolescents, Animal Study Suggests

diciembre del 2009

Reports animal study findings that suggest adolescents' heightened sensitivity to drug reward puts them at enhanced risk of addiction and may also increase their challenges in recovery.

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Reducing Postpartum Drug Use

diciembre del 2008

Highlights a computerized intervention that reduced new mothers' drug abuse in the first 4 months postpartum as reported in a clinical trial of 107 women who abused drugs.

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Serotonin System May Have Potential as a Target for Cocaine Medications

abril del 2007
Describes investigations to advance the development of potential drug abuse relapse prevention agents by targeting specific receptors of the neurochemical serotonin.

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Stress Receptor Mediates Lifelong Consequences of Early Trauma

noviembre del 2012

NIDA-supported research suggests that glucocorticoid receptor levels during early brain development affect the hard wiring of neural circuits that shape an individual’s basic emotional makeup. In mice, overexpression of the glucocorticoid gene in the first weeks after birth increased anxiety and response to cocaine in adulthood. These findings may help researchers understand the genetic background and the developmental trajectory of addiction.

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Stroop Test Identifies Patients at Risk for Treatment Dropout

abril del 2010
Reports on a study of cocaine abusers revealing that the Stroop test may predict which cocaine abusers are likely to drop out of therapy.

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Study Pinpoints Cognitive Deficits Due to Cocaine, Finds Potential for Recovery

agosto del 2013

New research demonstrated that, in rhesus monkeys, ongoing cocaine exposure weakens two brain functions that people require for successful behavioral change: cognitive flexibility and memory. But the study determined that these changes may not be permanent.

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Test Substance Attenuates Signs of Cocaine Withdrawal in Rats

diciembre del 2009

Reports on several drugs that may ward off depression and anxiety, common withdrawal symptoms from cocaine, based on an animal study.

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