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NIDA Notes Articles: Cocaína

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Physical Activity Reduces Return to Cocaine Seeking in Animal Tests

abril del 2012

Two independent animal studies suggest that aerobic exercise might help cocaine abusers establish and maintain abstinence.

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Prefrontal Cortex Stimulation Stops Compulsive Drug Seeking in Rats

enero del 2014

Researchers have shut down laboratory rats’ compulsive cocaine seeking by stimulating an area of the animals’ prefrontal cortex. The finding raises the possibility that stimulating neurons in this brain area may weaken or break cocaine’s grip on the behavior of people who are addicted to the drug.

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Prenatal Cocaine Exposure Increases Monkeys' Impulsivity Into Adulthood

julio del 2012

Prenatal drug exposure can have behavioral effects that last well into adulthood, according to two studies of adult monkeys prenatally exposed to cocaine. In the first study, drug-exposed monkeys exhibited less flexibility than controls in adjusting to changing circumstances; in the second study, drug-exposed males exhibited a greater preference than controls for having rewards right away, a sign of impulsivity.

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Program Helps Troubled Boys Reduce Substance Abuse

diciembre del 2011

Chronically delinquent boys in Multidimensional Treatment Foster Care reduced their substance abuse more than boys assigned to Community Group Care.

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Rare Glutamate Receptor Proliferates After Cocaine Withdrawal

diciembre del 2009

Reports findings that a rare neuroreceptor may be linked to the intensive cravings cocaine abusers experience during their first weeks of abstinence.

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Recovery May Be Harder for Adolescents, Animal Study Suggests

diciembre del 2009

Reports animal study findings that suggest adolescents' heightened sensitivity to drug reward puts them at enhanced risk of addiction and may also increase their challenges in recovery.

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Reducing Postpartum Drug Use

diciembre del 2008

Highlights a computerized intervention that reduced new mothers' drug abuse in the first 4 months postpartum as reported in a clinical trial of 107 women who abused drugs.

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Serotonin System May Have Potential as a Target for Cocaine Medications

abril del 2007
Describes investigations to advance the development of potential drug abuse relapse prevention agents by targeting specific receptors of the neurochemical serotonin.

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Stress Hormone Sets the Stage for Relapse to Cocaine Use

junio del 2015

A stressed rat will seek a dose of cocaine that is too weak to motivate an unstressed rat. Researchers traced the physiological pathway that links stress and the stress hormone corticosterone to increased dopamine activity and heightened responsiveness to cocaine.

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Stress Receptor Mediates Lifelong Consequences of Early Trauma

noviembre del 2012

NIDA-supported research suggests that glucocorticoid receptor levels during early brain development affect the hard wiring of neural circuits that shape an individual’s basic emotional makeup. In mice, overexpression of the glucocorticoid gene in the first weeks after birth increased anxiety and response to cocaine in adulthood. These findings may help researchers understand the genetic background and the developmental trajectory of addiction.

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