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NIDA Notes Articles: Cocaína

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Long-Term Cocaine Abuse Linked With Impaired Heart Function

Marzo del 2008
Summarizes research on the effects of long-term regular cocaine abuse on the cardiovascular system in African Americans.

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Long-Term Cocaine Self-Administration Depresses Brain Activity

diciembre del 2008

Discusses research exploring how widespread the reduction of neural activity is in the brain with chronic exposure to cocaine.

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Low Dopamine Receptor Availability May Promote Cocaine Addiction

abril del 2009

Describes findings from an animal study showing that cocaine lowers availability of dopamine receptors in the basal ganglia, an area of the brain that includes portions of the reward system.

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Male Rats’ Cocaine Exposure Affects Their Offspring’s Drug Responses

agosto del 2013

In a surprising finding, male rats who used cocaine sired male offspring who later exhibited blunted responses to the drug. Researchers determined the cause was an epigenetic alteration.

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Manic Mice Show Heightened Sensitivity to Rewards

octubre del 2009

Reports on an animal study suggesting that the manic stage of bipolar disorder promotes signs of drug abuse vulnerability by enhancing sensitivity to rewards, both natural and drug-related.

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Marijuana Use May Promote Nicotine Consumption

abril del 2014

Exposing rats to THC increases the likelihood that the animals will later self-administer nicotine. THC-exposed rats are also willing to work harder to obtain nicotine. When extrapolated to people, the findings suggest that THC’s pharmacological impact on the brain may make a person who uses marijuana more vulnerable to developing nicotine addiction, an underappreciated health consequence of marijuana use.

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Medications That Normalize Brain Glutamate Reduce Drug-Seeking in Rats

octubre del 2010
Reports on two studies that demonstrate the promise of treating addiction with medications that alleviate drug-induced alterations in signaling by the neurotransmitter glutamate.

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Methadone Reduces Rats' Cocaine Seeking

diciembre del 2008

Reports on an animal study showing that methadone, normally used as a therapy for opioid abuse, may prove to be an effective treatment for cocaine abuse.

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Methadone Therapy in Prison Benefits Men a Year Out

noviembre del 2009

Describes clinical trial results providing evidence that methadone maintenance to men in prison can pay off in better retention in community treatment and reduced drug abuse following their release.

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Methylphenidate for Comorbid Cocaine Abuse, ADHD

octubre del 2006
Describes an inpatient study investigating the effectiveness of sustained-release methylphenidate as a treatment for cocaine-addiction patients with ADHD.

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