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NIDA Notes Articles: Withdrawal

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Test Substance Attenuates Signs of Cocaine Withdrawal in Rats

diciembre del 2009

Reports on several drugs that may ward off depression and anxiety, common withdrawal symptoms from cocaine, based on an animal study.

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Study Finds Withdrawal No Easier With Ultrarapid Opiate Detox

octubre del 2006
Presents findings from a clinical trial comparing ultrarapid, anesthesia-assisted detoxification with detoxification by traditional methods among patients addicted to heroin.

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Sertraline Does Not Help Methamphetamine Abusers Quit

Marzo del 2008

Describes a new research finding indicating that the antidepressant sertraline (Zoloft), prescribed to relieve depression during the methamphetamine withdrawal process, may make quitting harder.

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Receptor May Underlie Gender Differences in Response to Smoking Cessation

mayo del 2013

Men benefit more than women from nicotine replacement therapy for smoking cessation because nicotine affects a key neuroreceptor differently in the two sexes, a NIDA-sponsored study suggests. The findings highlight the need for alternative therapies for women smokers, and point to the female hormone progesterone as a potential therapeutic target.

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Rare Glutamate Receptor Proliferates After Cocaine Withdrawal

diciembre del 2009

Reports findings that a rare neuroreceptor may be linked to the intensive cravings cocaine abusers experience during their first weeks of abstinence.

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Patch Delivers Buprenorphine for Heroin Detox

noviembre del 2009

Describes research on the effectiveness of a buprenorphine patch to alleviate opioid withdrawal symptoms of newly abstinent heroin abusers.

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Nicotine Boosts Mood, Brain Dopamine Levels

noviembre del 2009

Highlights findings from a study showing that nicotine triggers a surge in levels of the neurotransmitter dopamine in the brain's main reward area for cigarette smokers.

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More Convenient Preparations of Buprenorphine Pass Test

julio del 2012

Soluble-film preparations of buprenorphine suppressed heroin abusers’ withdrawal symptoms with no serious side effects in a recent clinical trial. They dissolved more rapidly in the mouth than the pill form of the medication, providing faster relief.

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Lofexidine May Enhance Naltrexone Efficacy

diciembre del 2008

Highlights results from a pilot study suggesting that lofexidine, an anti-hypertensive medication, can enhance success rates among patients taking maintenance naltrexone to avoid opioid relapse.

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Gabapentin Tested To Treat Marijuana Dependence

abril del 2013

Marijuana-dependent outpatients who were treated with the medication gabapentin in a pilot clinical trial reduced their cannabis use more and reported fewer symptoms of drug withdrawal than patients who received a placebo.

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