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NIDA Notes Articles: Withdrawal

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Receptor May Underlie Gender Differences in Response to Smoking Cessation

mayo del 2013

Men benefit more than women from nicotine replacement therapy for smoking cessation because nicotine affects a key neuroreceptor differently in the two sexes, a NIDA-sponsored study suggests. The findings highlight the need for alternative therapies for women smokers, and point to the female hormone progesterone as a potential therapeutic target.

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Gabapentin Tested To Treat Marijuana Dependence

abril del 2013

Marijuana-dependent outpatients who were treated with the medication gabapentin in a pilot clinical trial reduced their cannabis use more and reported fewer symptoms of drug withdrawal than patients who received a placebo.

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More Convenient Preparations of Buprenorphine Pass Test

julio del 2012

Soluble-film preparations of buprenorphine suppressed heroin abusers’ withdrawal symptoms with no serious side effects in a recent clinical trial. They dissolved more rapidly in the mouth than the pill form of the medication, providing faster relief.

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Buprenorphine During Pregnancy Reduces Neonate Distress

julio del 2012

Sublingual buprenorphine is a safe and effective alternative to methadone for treating opioid dependence during pregnancy, finds the Maternal Opioid Treatment: Human Experimental Research (MOTHER) study, a NIDA-supported clinical trial. Women who received either medication had similar pregnancy and birth outcomes, but infants born to women who received buprenorphine had milder symptoms of neonatal opioid withdrawal.

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Disruption of Neuron Production in Adult Rats Increases Cocaine Taking

noviembre del 2011
Drug abuse may diminish production of new neurons in the brain’s hippocampus and thereby increase vulnerability to drug addiction.

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Rare Glutamate Receptor Proliferates After Cocaine Withdrawal

diciembre del 2009

Reports findings that a rare neuroreceptor may be linked to the intensive cravings cocaine abusers experience during their first weeks of abstinence.

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Test Substance Attenuates Signs of Cocaine Withdrawal in Rats

diciembre del 2009

Reports on several drugs that may ward off depression and anxiety, common withdrawal symptoms from cocaine, based on an animal study.

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Nicotine Boosts Mood, Brain Dopamine Levels

noviembre del 2009

Highlights findings from a study showing that nicotine triggers a surge in levels of the neurotransmitter dopamine in the brain's main reward area for cigarette smokers.

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Patch Delivers Buprenorphine for Heroin Detox

noviembre del 2009

Describes research on the effectiveness of a buprenorphine patch to alleviate opioid withdrawal symptoms of newly abstinent heroin abusers.

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Lofexidine May Enhance Naltrexone Efficacy

diciembre del 2008

Highlights results from a pilot study suggesting that lofexidine, an anti-hypertensive medication, can enhance success rates among patients taking maintenance naltrexone to avoid opioid relapse.

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