In English
NIDA

NIDA Notes Articles: Medication Development

NIDA Notes Category Graphic

Gabapentin Tested To Treat Marijuana Dependence

abril del 2013

Marijuana-dependent outpatients who were treated with the medication gabapentin in a pilot clinical trial reduced their cannabis use more and reported fewer symptoms of drug withdrawal than patients who received a placebo.

NIDA Notes Category Graphic

How Drug Abuse Affects the Brain and Alters Behavior Are Key Questions Driving Division's Work

febrero del 2007
Discusses the work of NIDA’s Division of Basic Neuroscience and Behavioral Research, the Institute’s locus for studies into the fundamental brain mechanisms underlying drug abuse and addiction.

NIDA Notes Category Graphic

In Animals, Receptor Puts Brakes on Nicotine Consumption

Marzo del 2012

New research suggests that differences in tobacco consumption reflect, in part, differences in the functional efficacy of a specific type of receptor in a pathway of the brain. In animal studies, nicotinic acetylcholine receptors with the α5 subunit played a key role in producing aversive responses to nicotine, thereby dissuading further consumption of the drug.

NIDA Notes Category Graphic

Lofexidine May Enhance Naltrexone Efficacy

diciembre del 2008

Highlights results from a pilot study suggesting that lofexidine, an anti-hypertensive medication, can enhance success rates among patients taking maintenance naltrexone to avoid opioid relapse.

NIDA Notes Category Graphic

Medication Reduces Rats' Return to Methamphetamine Seeking

julio del 2011

Reports on a new medication strategy under investigated in animal studies that shows promise for preventing relapse to drug abuse.

NIDA Notes Category Graphic

Medications That Normalize Brain Glutamate Reduce Drug-Seeking in Rats

octubre del 2010
Reports on two studies that demonstrate the promise of treating addiction with medications that alleviate drug-induced alterations in signaling by the neurotransmitter glutamate.

NIDA Notes Category Graphic

Microneedle Milestone: One Week of Transdermal Drug Delivery

Marzo del 2014

Microneedles are an innovative technique for delivering medications through the skin, a route that could particularly benefit patients receiving naltrexone therapy for opioid and alcohol dependence. Researchers have found a way to use the transdermal technique to deliver a single treatment of naltrexone that lasts for 7 days.

NIDA Notes Category Graphic

Modafinil Normalizes Sleep During Early Cocaine Abstinence

diciembre del 2010
Describes a study investigating the effectiveness of modafinil in enhancing sleep among cocaine abusers who are currently abstinent.

NIDA Notes Category Graphic

More Convenient Preparations of Buprenorphine Pass Test

julio del 2012

Soluble-film preparations of buprenorphine suppressed heroin abusers’ withdrawal symptoms with no serious side effects in a recent clinical trial. They dissolved more rapidly in the mouth than the pill form of the medication, providing faster relief.

NIDA Notes Category Graphic

N-Acetylcysteine Postsynaptic Effect Limits Efficacy

enero del 2013

Clinical trials of N-acetylcysteine to help people recovering from drug abuse avoid relapse have demonstrated only moderate efficacy. New NIDA-supported research shows that while a low dose of the medication activates receptors associated with lowered drug-seeking behavior, a higher dose appears to activate receptors associated with increased drug-seeking behavior. The result suggests that a medication or combination of medications that stimulate the receptor GluR2/3 and block mGluR5 may work better than N-acetylcysteine alone.

Páginas

NIDA Notes

Tags

Drug Topics

Drugs of Abuse

Population Groups

Related Topics

Toma el reto nacional sobre el coeficiente intelectual (CI) sobre las drogas