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NIDA Notes Articles: Medication Development

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Well-Known Mechanism Underlies Benzodiazepines' Addictive Properties

abril del 2012
New research establishes that benzodiazepines cause addiction in a way similar to that of opioids, cannabinoids, and the club drug GHB. The discovery opens the door to designing new benzodiazepines that counteract anxiety but are not addictive.

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Vaccine May Reduce Fetal Exposure to Nicotine

abril del 2007
Describes research on a vaccine developed to facilitate smoking cessation by blocking nicotine penetration into the brain.

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Three Scientists Join Advisory Council

diciembre del 2010
Announces three new NIDA National Advisory Council on Drug Abuse members and describes their drug abuse and addiction research experience.

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Test Substance Attenuates Signs of Cocaine Withdrawal in Rats

diciembre del 2009

Reports on several drugs that may ward off depression and anxiety, common withdrawal symptoms from cocaine, based on an animal study.

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Stress-Induced Enzyme Compounds Methamphetamine Neurotoxicity

enero del 2014

Ketoprofen, an anti-inflammatory agent commonly prescribed to treat arthritis, reduces neuronal damage in rats that have been exposed to chronic stress and methamphetamine. If this finding of a recent NIDA-supported study extrapolates to humans, anti-inflammatory medications may gain a place in the treatment of methamphetamine addiction.

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Selenium Shows Promise as an Adjunct Therapy for HIV

diciembre del 2008

Reports on a randomized controlled trial of HIV-infected men and women who, as a result of receiving selenium supplements, experienced lower HIV viral load and greater CD4 cell count.

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Q&A: Dr. David Thomas

noviembre del 2012

NIDA Program Officer Dr. David Thomas speaks about the intertwined problems of pain and prescription opioid abuse, as well as the research supported by NIDA and the National Institutes of Health to address these problems.

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Potential Pain Medication Targets Peripheral Nerves

septiembre del 2012

Researchers report a significant advance in the search for medications that can suppress pain but avoid opioids’ abuse potential and other undesirable CNS effects. A new compound reduces mouse responses in animal models of neurogenic and chronic inflammatory (e.g., arthritic) pain. The compound, called UB937, enhances the natural pain-killing activity of the neurotransmitter anandamide, and exerts its analgesic effects entirely in peripheral tissues, without entering the brain.

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Oxycodone Vaccine Passes Early Tests

mayo del 2013

A new vaccine hindered the often-abused prescription opioids oxycodone and hydrocodone from entering the brain and suppressed one of the drugs’ signature central nervous system effects. The findings warrant continued development of the vaccine as a potential aid in the treatment of oxycodone and hydrocodone abuse and dependence.

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NIDA Appoints New Director of the Intramural Research Program

diciembre del 2010
Announces NIDA’s new director of its intramural research program, Antonello Bonci, M.D., a leading researcher in neuropsychopharmacology.

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Toma el reto nacional sobre el coeficiente intelectual (CI) sobre las drogas