In English
NIDA

NIDA Notes Articles: Medication Development

NIDA Notes Category Graphic

N-Acetylcysteine Postsynaptic Effect Limits Efficacy

enero del 2013

Clinical trials of N-acetylcysteine to help people recovering from drug abuse avoid relapse have demonstrated only moderate efficacy. New NIDA-supported research shows that while a low dose of the medication activates receptors associated with lowered drug-seeking behavior, a higher dose appears to activate receptors associated with increased drug-seeking behavior. The result suggests that a medication or combination of medications that stimulate the receptor GluR2/3 and block mGluR5 may work better than N-acetylcysteine alone.

NIDA Notes Category Graphic

Gabapentin Tested To Treat Marijuana Dependence

abril del 2013

Marijuana-dependent outpatients who were treated with the medication gabapentin in a pilot clinical trial reduced their cannabis use more and reported fewer symptoms of drug withdrawal than patients who received a placebo.

NIDA Notes Category Graphic

Oxycodone Vaccine Passes Early Tests

mayo del 2013

A new vaccine hindered the often-abused prescription opioids oxycodone and hydrocodone from entering the brain and suppressed one of the drugs’ signature central nervous system effects. The findings warrant continued development of the vaccine as a potential aid in the treatment of oxycodone and hydrocodone abuse and dependence.

NIDA Notes Category Graphic

Naltrexone Implant Outperforms Daily Pill in Russian Trial

noviembre del 2013

More than half of heroin-addicted patients treated with naltrexone via an implanted delivery device maintained abstinence throughout a 6-month clinical trial in Saint Petersburg, Russia. The implant device, which releases a steady dose of naltrexone continuously for 2 months, averted relapse to heroin use three times as effectively as daily oral doses of the medication.

NIDA Notes Category Graphic

Stress-Induced Enzyme Compounds Methamphetamine Neurotoxicity

enero del 2014

Ketoprofen, an anti-inflammatory agent commonly prescribed to treat arthritis, reduces neuronal damage in rats that have been exposed to chronic stress and methamphetamine. If this finding of a recent NIDA-supported study extrapolates to humans, anti-inflammatory medications may gain a place in the treatment of methamphetamine addiction.

NIDA Notes Category Graphic

Microneedle Milestone: One Week of Transdermal Drug Delivery

Marzo del 2014

Microneedles are an innovative technique for delivering medications through the skin, a route that could particularly benefit patients receiving naltrexone therapy for opioid and alcohol dependence. Researchers have found a way to use the transdermal technique to deliver a single treatment of naltrexone that lasts for 7 days.

NIDA Notes Category Graphic

Dr. Kevin M. Gray Q & A: A Potential Medication for Marijuana Dependence

octubre del 2014

Dr. Kevin M. Gray discusses why it’s the perfect time for discovering new evidence-based treatments for marijuana dependence. In an accompanying podcast, he discusses a clinical trial that examines NAC’s potential as a treatment for marijuana dependence among adults.

Pages

NIDA Notes

Tags

Drug Topics

Drugs of Abuse

Population Groups

Related Topics

Toma el reto nacional sobre el coeficiente intelectual (CI) sobre las drogas